Abstract
Insoluble cereal fibres have been shown in large prospective cohort studies to be highly effective in preventing type 2 diabetes, but there is a lack of interventional data. Our 2 year randomised double-blind prospective intervention study compared the effect of an insoluble oat fibre extract with that of placebo on glucose metabolism and incidence of diabetes. A total of 180 participants with impaired glucose tolerance underwent a modified version of the 1 year lifestyle training programme PREvention of DIAbetes Self-management (PREDIAS) and were randomised to receive a fibre supplement (n = 89; 7.5 g of insoluble fibre per serving) or placebo (n = 91; 0.8 g of insoluble fibre per serving) twice daily for 2 years. Eligible participants were men and women, were at least 18 years old and did not report corticosteroid or other intensive anti-inflammatory treatment, fibre intolerance or any of the following disorders: overt diabetes, chronic or malignant disease, or severe cardiopulmonary, endocrine, psychiatric, gastrointestinal, autoimmune or eating disorder. Participants were recruited at two clinical wards in Berlin and Nuthetal. The allocation was blinded to participants and study caregivers (physicians, dietitians, study nur...Continue Reading
References
Oct 1, 1990·Diabetes Research and Clinical Practice·J Cederholm, L Wibell
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Apr 1, 1997·Diabetes Care·X R PanB V Howard
May 1, 1998·Molecular Genetics and Metabolism·F BelfioreG Volpicelli
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Apr 25, 2003·Diabetologia·M D RobertsonK N Frayn
May 19, 2005·European Journal of Clinical Nutrition·K HermansenA Astrup
Sep 21, 2005·Diabetologia·M O WeickertA F H Pfeiffer
Jan 5, 2006·Diabetologia·A RamachandranUNKNOWN Indian Diabetes Prevention Programme (IDPP)
Mar 17, 2006·Diabetologia·J LindströmJ Tuomilehto
Mar 29, 2006·Diabetes Care·Martin O WeickertAndreas F H Pfeiffer
Apr 25, 2006·Metabolism: Clinical and Experimental·Ikram AloulouJacques Mercier
Nov 14, 2006·Lancet·Jaana LindströmUNKNOWN Finnish Diabetes Prevention Study Group
May 16, 2007·Archives of Internal Medicine·Matthias B SchulzeHeiner Boeing
Sep 1, 2007·PLoS Medicine·Jeroen S L de MunterRob M van Dam
Feb 22, 2008·The Journal of Nutrition·Martin O Weickert, Andreas F H Pfeiffer
Apr 17, 2009·The Journal of Nutritional Biochemistry·Frank IskenMartin O Weickert
Apr 24, 2009·The American Journal of Clinical Nutrition·Jill A Parnell, Raylene A Reimer
Jun 11, 2009·Diabetes Care·Bernhard KulzerThomas Haak
Aug 12, 2009·The British Journal of Nutrition·Kristin R FreelandThomas M S Wolever
Apr 28, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J LindströmT Yilmaz
Jun 3, 2011·The American Journal of Clinical Nutrition·Martin O WeickertAndreas F H Pfeiffer
Jun 1, 2012·The American Journal of Clinical Nutrition·Morten Georg JensenArne Astrup
Sep 13, 2013·Diabetes Care·Olga PivovarovaNatalia Rudovich
Jun 10, 2014·Lancet·Sylvia H LeyFrank B Hu
Jul 7, 2017·The American Journal of Clinical Nutrition·Mads F HjorthArne Astrup
Citations
Aug 25, 2018·Expert Review of Endocrinology & Metabolism·Martin O Weickert
Dec 7, 2018·Expert Review of Endocrinology & Metabolism·Orsolya M PalaciosKevin C Maki
Feb 6, 2019·The American Journal of Clinical Nutrition·Caroline WillmannAndreas Fritsche
Oct 9, 2019·Nutrients·Stefan KabischAndreas F H Pfeiffer
Sep 12, 2018·Nutrients·Nicola D Guess
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Nov 14, 2019·Nutrients·Stefan KabischAndreas F H Pfeiffer
Oct 9, 2020·Nutrients·Nirmala Prasadi V P, Iris J Joye
Dec 10, 2020·The Journal of Nutrition·Angela S DoninPeter H Whincup
Jan 13, 2021·International Journal of Molecular Sciences·Thomas M BarberMartin O Weickert
Oct 25, 2020·Nutrients·Thomas M BarberMartin O Weickert
Apr 4, 2021·Nutrients·Oliver ChenYiFang Chu
Apr 4, 2021·Nutrients·Xinye LiMaxim S Petrov
May 1, 2021·Nutrients·Thomas M BarberMartin O Weickert
Apr 29, 2021·Molecular Nutrition & Food Research·Stefan KabischAndreas F H Pfeiffer
Jul 14, 2021·Acta Diabetologica·Stefan KabischAndreas F H Pfeiffer