Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

Diabetologia
Caroline HonsekAndreas F H Pfeiffer

Abstract

Insoluble cereal fibres have been shown in large prospective cohort studies to be highly effective in preventing type 2 diabetes, but there is a lack of interventional data. Our 2 year randomised double-blind prospective intervention study compared the effect of an insoluble oat fibre extract with that of placebo on glucose metabolism and incidence of diabetes. A total of 180 participants with impaired glucose tolerance underwent a modified version of the 1 year lifestyle training programme PREvention of DIAbetes Self-management (PREDIAS) and were randomised to receive a fibre supplement (n = 89; 7.5 g of insoluble fibre per serving) or placebo (n = 91; 0.8 g of insoluble fibre per serving) twice daily for 2 years. Eligible participants were men and women, were at least 18 years old and did not report corticosteroid or other intensive anti-inflammatory treatment, fibre intolerance or any of the following disorders: overt diabetes, chronic or malignant disease, or severe cardiopulmonary, endocrine, psychiatric, gastrointestinal, autoimmune or eating disorder. Participants were recruited at two clinical wards in Berlin and Nuthetal. The allocation was blinded to participants and study caregivers (physicians, dietitians, study nur...Continue Reading

Associated Clinical Trials

Sep 7, 2012·Prof. Dr. med. Andreas F. H. Pfeiffer

References

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Feb 22, 2008·The Journal of Nutrition·Martin O Weickert, Andreas F H Pfeiffer
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Sep 13, 2013·Diabetes Care·Olga PivovarovaNatalia Rudovich

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Citations

Aug 25, 2018·Expert Review of Endocrinology & Metabolism·Martin O Weickert
Dec 7, 2018·Expert Review of Endocrinology & Metabolism·Orsolya M PalaciosKevin C Maki
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Oct 9, 2020·Nutrients·Nirmala Prasadi V P, Iris J Joye
Jan 13, 2021·International Journal of Molecular Sciences·Thomas M BarberMartin O Weickert
Oct 25, 2020·Nutrients·Thomas M BarberMartin O Weickert
Apr 4, 2021·Nutrients·Oliver ChenYiFang Chu
Apr 29, 2021·Molecular Nutrition & Food Research·Stefan KabischAndreas F H Pfeiffer

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