Fibrillarin from Archaea to human

Biology of the Cell
Ulises Rodriguez-CoronaEnrique Castano

Abstract

Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J P Aris, G Blobel
Jan 1, 1985·Biology of the Cell·R L OchsH Busch
Apr 1, 1993·Trends in Biochemical Sciences·M J Fournier, E S Maxwell
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·C LiuD Mercola
Jun 1, 1997·Molecular Biology of the Cell·E DavidR E Pearlman
Sep 25, 1999·Protein Expression and Purification·D L PearsonK M Pollard
Nov 24, 1999·Molecular and Cellular Biology·D KresslerJ de La Cruz
Apr 15, 2000·Nature·R D Phair, T Misteli
Aug 10, 2000·Molecular Biology of the Cell·T DoussetS Huang
Nov 4, 2000·The Journal of Cell Biology·S SnaarR W Dirks
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Arina D OmerPatrick P Dennis
Jul 12, 2002·Archives of Virology·J A Hiscox
Feb 21, 2004·Biochemical and Biophysical Research Communications·Lu DengBi-Cheng Wang
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Adam AmsterdamNancy Hopkins
Sep 9, 2004·The Journal of Cell Biology·Anthony Kar Lun LeungAngus I Lamond
Jan 7, 2005·Nature·Jens S AndersenMatthias Mann
Apr 9, 2005·Molecular Biology of the Cell·Nicole AngelierDanièle Hernandez-Verdun
Feb 7, 2006·Biochemical Pharmacology·R A AlderdenR Callaghan
Mar 24, 2006·Nature·Nevan J KroganJack F Greenblatt
Apr 25, 2006·Molecular Cell·Anders M HinsbySøren Brunak
Feb 8, 2007·Nucleic Acids Research·Steve L ReichowGabriele Varani
May 24, 2007·Nature Reviews. Molecular Cell Biology·François-Michel BoisvertAngus I Lamond
Jun 6, 2007·The Journal of Cell Biology·Eric MorencyPatrick Lomonte
Jun 15, 2007·Molecular Cell·Stefan BäckströmStefan Björklund
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sang Hyon KimMichael Taliansky
Jul 3, 2007·Biochemical and Biophysical Research Communications·Mohammed Abdullahel AminKiichi Fukui
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Philip Ian PadillaMartha Vaughan

❮ Previous
Next ❯

Citations

Feb 6, 2016·Histochemistry and Cell Biology·Klara Weipoltshammer, Christian Schöfer
Nov 26, 2015·Frontiers in Plant Science·Lloyd Loza-MullerEnrique Castano
Mar 24, 2016·Nucleus·Tian-Hsiang MaSzecheng J Lo
Dec 10, 2016·Journal of Peptide Science : an Official Publication of the European Peptide Society·Soledad AstradaMariela Bollati-Fogolín
Oct 11, 2017·Aging Cell·Francesca E DuncanJennifer L Gerton
Aug 7, 2018·Cell Biology International·Maria Y ShubinaEugene V Sheval
Oct 5, 2018·Biomolecules·Piero Lo MonacoFrédéric Catez
May 22, 2020·British Journal of Pharmacology·Brizaida Oliva ArguellesMaribel Guerra Vallespi
Nov 23, 2017·Frontiers in Plant Science·Ulises Rodriguez-CoronaEnrique Castano
Feb 16, 2019·Genes·Dilyana G DimitrovaClément Carré
Nov 22, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jenny EralesJean-Jacques Diaz
Sep 30, 2016·Biochemistry. Biokhimii︠a︡·M Y ShubinaE V Sheval
Dec 4, 2019·Scientific Reports·Carlos BuenoSalvador Martínez
Aug 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lian ZhuClifford P Brangwynne
May 27, 2021·Molecular Biology Reports·Stefano Decle-CarrascoEnrique Castano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.