Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers

Biochemical and Biophysical Research Communications
Ira SuroliaSharmistha Sinha

Abstract

In this study, biphenyl ethers of diverse functionality were used to assess their effect on fibrillogenesis of both the oxidized and reduced ADan peptides, in vitro. It was noted that these compounds not only stalled fibrillogenesis but were also able to disrupt pre-formed fibers. The EC(50) values for the inhibition of this process lie in the nanomolar range for 50 microM of peptide concentration, indicating the high potency of these compounds as inhibitors. It was found that these compounds impart to the peptides, an alpha-helical conformation which does not allow them to aggregate and form fibrils. These studies also point out that the transition of peptides through alpha-helical conformation may be a prelude to the onset of fibrillogenesis for oxADan peptides.

References

Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C Ionescu-ZanettiA L Fink
Dec 22, 2004·The Journal of Biological Chemistry·Sayuri TaniguchiMasato Hasegawa
Feb 14, 2006·Trends in Biochemical Sciences·Claudio SotoJoaquín Castilla
Feb 24, 2006·Nature Structural & Molecular Biology·Thomas R JahnSheena E Radford
Oct 5, 2006·Brain : a Journal of Neurology·Hans-Wolfgang KlafkiJens Wiltfang
Oct 13, 2006·Journal of Neurochemistry·Ira SuroliaSharmistha Sinha
Nov 3, 2006·Nature Reviews. Drug Discovery·Debby Van Dam, Peter Paul De Deyn
Nov 4, 2006·Science·Erik D Roberson, Lennart Mucke
Dec 16, 2006·Current Alzheimer Research·Mathew Blurton-Jones, Frank M Laferla
May 19, 2007·Current Topics in Medicinal Chemistry·Buyong Ma, Ruth Nussinov

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Citations

Feb 22, 2017·Biomolecular Concepts·G Bhanuprakash ReddyAvadhesha Surolia

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