Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

Chemical Communications : Chem Comm
Jillian MadineDavid A Middleton

Abstract

The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

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Citations

Jan 11, 2013·Journal of the Royal Society, Interface·Tais A P F DollPeter Burkhard
Jun 8, 2014·Biochimica Et Biophysica Acta·Matjaž Zganec, Eva Zerovnik
Dec 15, 2015·Physical Chemistry Chemical Physics : PCCP·David ZanuyCarlos Alemán
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Oct 10, 2020·Chemical Communications : Chem Comm·Valeria CastellettoIan W Hamley
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Mar 5, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Dongdong LinXinju Yang

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