Fibrin glue for sealing the needle track after percutaneous lung biopsy: Part I--Experimental study

Cardiovascular and Interventional Radiology
T PetsasI Fezoulidis

Abstract

Evaluate the effectiveness of fibrin glue for the embolic occlusion of needle tracks following percutaneous lung biopsy (PLB). Twenty-six rabbits underwent computed tomography (CT)-guided PLB using a coaxial system consisting of 19- and 22-gauge needles. Thirteen rabbits were used as controls (group A). In 13 other rabbits (group B), fibrin glue labelled with I131 fibrinogen and contrast medium was injected into the track. Both groups were examined by CT for the presence and severity of pneumothorax (mild: less than 20%; severe: more than 20%). Group B was also examined scintigraphically and their lungs were studied histologically. In group A, pneumothorax developed in eight animals (61.6%) and was severe in six (46.1%) whereas in group B, pneumothorax developed in five animals (38.5%) and was severe in one (7.7%). Though the difference between the two groups in overall incidence of pneumothorax was not significant (p > 0.1), it was significantly higher (p < 0.025) for severe pneumothorax in group A. No signs of systemic embolism were observed. Based on this animal model, fibrin glue is a safe and useful sealant following PLB and reduces the incidence of severe pneumothorax.

References

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Citations

Mar 29, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·B A FeitoJ Azorin
Jul 16, 2005·European Journal of Radiology·U Topal, Yahya M Berkman
Jun 1, 1997·Pediatric Clinics of North America·P Chait
Jan 27, 2017·Biomacromolecules·Richard D O'RorkeTerry W J Steele
Mar 17, 2017·AJR. American Journal of Roentgenology·Bernhard GlodnyRafael Rehwald
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marie LignieresJean Izaaryene
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jean IzaaryeneJean-Yves Gaubert

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