Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

Neuron
Katerina AkassoglouSidney Strickland

Abstract

Remyelination is a critical step for functional nerve regeneration. Here we show that fibrin deposition in the peripheral nervous system after injury is a key regulator of remyelination. After sciatic nerve crush, fibrin is deposited and its clearance correlates with remyelination. Fibrin induces phosphorylation of ERK1/2 and production of p75 NGF low-affinity receptor in Schwann cells and maintains them in a nonmyelinating state, suppresses fibronectin production, and prevents synthesis of myelin proteins. In mice depleted of fibrin(ogen), remyelination of myelinated axons is accelerated due to the faster transition of the Schwann cells to a myelinating state. Regulation of fibrin clearance and/or deposition could be a key regulatory mechanism for Schwann differentiation after nerve damage.

References

Jan 1, 1991·Annual Review of Neuroscience·L F Reichardt, K J Tomaselli
Jan 1, 1986·Annual Review of Neuroscience·R P BungeC F Eldridge
Nov 23, 1971·Biochemistry·R Chen, R F Doolittle
Feb 1, 1970·Experimental Neurology·W G Bradley, A K Asbury
Oct 8, 1969·Biochemical and Biophysical Research Communications·L LorandR A Domanik
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Oct 1, 1994·Journal of Neurobiology·C Fernandez-ValleM B Bunge
Dec 1, 1994·Journal of Neurology·P M Richardson, X Lu
Dec 1, 1993·The Journal of Experimental Medicine·L Tang, J W Eaton
Apr 1, 1996·Current Opinion in Cell Biology·R Treisman
Mar 1, 1996·Trends in Genetics : TIG·C Kioussi, P Gruss
Dec 1, 1996·Current Opinion in Cell Biology·T S Zorick, G Lemke
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Mar 3, 1997·The Journal of Experimental Medicine·A R KitchingP G Tipping
Apr 1, 1997·Journal of Anatomy·A M RobertsonP K Thomas
Apr 29, 1998·Brain : a Journal of Neurology·P M HughesK M Miller
May 26, 1998·Journal of Neuropathology and Experimental Neurology·R A Sobel
Jul 3, 1998·The Journal of Clinical Investigation·N BussoA So
Jul 11, 1998·The Journal of Biological Chemistry·M F FavataJ M Trzaskos
Mar 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I FriedmannM Schwartz
May 5, 1999·American Journal of Respiratory Cell and Molecular Biology·R L PerezJ Roman
May 26, 1999·Journal of Neuroscience Research·M G VogelezangC ffrench-Constant
Jul 30, 1999·Journal of Neuroimmunology·W F Blakemore, H S Keirstead
Aug 11, 1999·Trends in Neurosciences·K R Jessen, R Mirsky
Dec 2, 1999·Journal of Neuroimmunology·J L RutkowskiS L Kunkel
Jan 15, 2000·Advances in Experimental Medicine and Biology·K R Jessen, R Mirsky

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Citations

Nov 1, 2011·Seminars in Immunopathology·Dimitrios Davalos, Katerina Akassoglou
Aug 19, 2011·Cell and Tissue Research·Kristina Beck, Christian Schachtrup
Dec 18, 2010·Cellular and Molecular Neurobiology·Yang YangWei-ping Wu
Dec 4, 2003·Experimental Cell Research·Michael A Chernousov, David J Carey
Feb 13, 2003·Neuroscience Letters·Katerina AkassoglouSidney Strickland
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katerina AkassoglouSidney Strickland
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kumar ShanmukhappaJorge A Bezerra
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·David B ArthurPaul A Insel
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian SchachtrupKaterina Akassoglou
Aug 1, 2007·The Journal of Experimental Medicine·Justin PaulJerry P Melchor
Mar 13, 2008·Tissue Engineering. Part a·Offra Sarig-Nadir, Dror Seliktar
Sep 3, 2011·Tissue Engineering. Part a·Alan J ManPeter Bannerman
Feb 2, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hung-Chou KuoLong-Sun Ro
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A PetzoldG Giovannoni
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
Aug 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Minlin XuJason X-J Yuan
Jul 11, 2006·Medicine and Science in Sports and Exercise·Tae Beom SeoUk Namgung
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian SchachtrupKaterina Akassoglou
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elisabetta MantuanoW Marie Campana
Sep 30, 2004·Science's STKE : Signal Transduction Knowledge Environment·Ru-Rong Ji, Gary Strichartz
Oct 21, 2004·Glia·Iordanis Gravanis, Stella E Tsirka
Jan 3, 2013·Trends in Molecular Medicine·Ravid Shechter, Michal Schwartz
Feb 11, 2015·Journal of Neuropathology and Experimental Neurology·Nádia Pereira GonçalvesMaria João Saraiva
Jan 18, 2006·Journal of Neuropathology and Experimental Neurology·Tie ZouHouyan Song
Dec 17, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Jonas PetterssonLiudmila N Novikova
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Jean-Philippe CamdessanchéJean-Christophe Antoine
Jul 9, 2004·The EMBO Journal·Marie C HarrisinghAlison C Lloyd
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·J K RyuK Akassoglou
May 3, 2008·Journal of Cellular Physiology·Lorena PerroneMariarosa Ab Melone
Dec 18, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Laurence B KemptonJames M Kerns
Jul 23, 2011·Developmental Neurobiology·Kim M Baeten, Katerina Akassoglou

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