PMID: 15348561Sep 7, 2004Paper

Fibrin-mediated endothelial cell adhesion to vascular biomaterials resists shear stress due to flow

Journal of Materials Science. Materials in Medicine
T R Santhosh Kumar, Lissy K Krishnan

Abstract

In vitro endothelial cell (EC) seeding onto biomaterials for blood-contacting applications can improve the blood compatibility of materials. Adhesive proteins adsorbed from serum that is supplemented with the culture medium intercede the initial cell adhesion and subsequent spreading on material surface during culture. Nevertheless, physical and chemical properties of vascular biomaterial surface fluctuate widely between materials resulting in dissimilarity in protein adsorption characteristics. Thus, a variation is expected in cell adhesion, growth and the ability of cell to resist shear stress when tissue engineering on to vascular biomaterials is attempted. This study was carried out with an objective to determine the significance of a matrix coating on cell adhesion and shear stress resistance when cells are cultured on materials such as polytetrafluoroethylene (PTFE, Teflon) and polyethyleneterephthalate (Dacron), ultra high molecular weight polyethylene (UHMWPE) and titanium (Ti), that are used for prosthetic devices. The study illustrates the distinction of EC attachment and proliferation between uncoated and matrix-coated surfaces. The cell attachment and proliferation on uncoated UHMWPE and titanium surfaces were not s...Continue Reading

Citations

Jan 13, 2012·Journal of Biomedical Materials Research. Part a·M Walkowiak-PrzybyłoB Walkowiak
Mar 31, 2011·Biotechnology and Applied Biochemistry·Meghna S MotwaniAlexander M Seifalian
Dec 22, 2016·Journal of Biomedical Materials Research. Part a·Maria Isabel CastellanosJose María Manero
Mar 15, 2020·Journal of Biomedical Materials Research. Part a·Caroline RoyerMarie-Christine Durrieu

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