Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty.

Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology
Luigi SabatiniRoberto Scagnelli

Abstract

Blood transfusion is often required in total knee replacement; various methods of blood preservation have been studied. The best solution is to reduce the loss of blood during and after surgery. We designed this study to evaluate the hemostatic efficacy and safety of fibrin tissue adhesive (Quixil) in patients receiving total knee arthroplasty [low contact stress (LCS, DePuy, Warsaw, IN, US) cementless total knee replacement (TKR)] with a prospective, randomized, standard treatment controlled study. Thirty-five patients were randomized to receive treatment with fibrin tissue adhesive (treatment group), and 35 were randomized to be managed with postoperative blood recovery and reinfusion (control group). Blood loss in suction drain, decrease in hemoglobin values, and transfusions were recorded. A significant reduction in apparent total blood loss was detected in the treatment group compared with the control group. There was also a lower decrease in hemoglobin level, although this difference was not significant. When fibrin tissue adhesive was administered, the need for transfusions was lower. No major adverse events were recorded in our series. Fibrin tissue adhesive reduced blood loss in TKR and seemed to significantly reduce t...Continue Reading

Associated Clinical Trials

References

Jul 31, 1999·The Journal of Arthroplasty·W A CurtinW D Spotnitz
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Citations

Jul 12, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Carlo L RomanòLorenzo Drago
Sep 3, 2014·Archives of Orthopaedic and Trauma Surgery·Luigi SabatiniAlessandro Massè
Aug 26, 2014·Journal of the American College of Surgeons·Aryeh ShanderVictor A Ferraris
Nov 19, 2014·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Luca Pierannunzii, Marco d'Imporzano
Jun 3, 2014·Journal of Orthopaedic Surgery and Research·Hongsheng WangZhengdong Cai
Sep 17, 2015·Clinical Oral Investigations·José López-LópezJesus Murat
Feb 15, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Zhi-Jun LiWei-Min Deng
Jan 13, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·T Q YangQ Zhang
Feb 17, 2015·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C ChoufaniG Versier
Jan 24, 2012·The Journal of Arthroplasty·R Carter ClementGwo-Chin Lee
Jan 5, 2017·Health Technology Assessment : HTA·Steven J EdwardsVictoria Wakefield
Jul 28, 2016·BMC Musculoskeletal Disorders·P PinsornsakS Chumchuen
Dec 3, 2013·JBJS Reviews·Atul F Kamath, Mark W Pagnano
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Zixian BaoMo Xian
Dec 20, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Milan KrtičkaLucy Vojtová
Mar 13, 2021·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Luke StanisceYekaterina Koshkareva
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shengnan LiJun Fu
Jun 12, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jong-Keun KimHyuk-Soo Han

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