PMID: 9159836Mar 1, 1997Paper

Fibrinogen and fibrinolytic activity in CAPD patients with atherosclerosis and its correlation with serum albumin

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
K J KimJ S Park

Abstract

It has been suggested that hypoalbuminemia in dialysis patients leads to a hypercoagulable state, however, the relationship between serum albumin and fibrinogen or fibrinolytic activity has not been well-documented. The aim of this study was to investigate the changes of fibrinogen, tissue plasminogen activator (tPA), plasminogen activator inhibitor type-1 (PAI-1), and lipid levels in continuous ambulatory peritoneal dialysis (CAPD) patients with atherosclerosis, and the relationship between those factors and serum albumin. A cross-sectional study. A university hospital. Twenty CAPD patients with atherosclerosis, 49 CAPD patients without atherosclerosis, and 33 normal controls were included. Presence of atherosclerosis was determined by positive results in a stress thallium single-photon emission computed tomography or an ankle brachial index less than 0.9. Coronary angiography and/or Doppler ultrasound of extremities were followed for the patients with positive results to confirm atherosclerotic cardiovascular disease. tPA and PAI-1 levels were determined with ELISA method, and fibrinogen with thrombin time method. Serum albumin and lipids were also measured. Serum albumin and HDL-cholesterol levels were significantly lower, a...Continue Reading

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