May 31, 2006

Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Kai ZacharowskiPeter Petzelbauer

Abstract

The occlusion of a coronary artery leads to ischemia of the myocardium, while permanent occlusion results in cell death and myocardial dysfunction. Early restoration of blood flow is the only means to reduce or prevent myocardial necrosis, but-paradoxically-reperfusion itself contributes to injury of the heart. In animal models, this phenomenon is well described, and there are many different unrelated approaches to reduce reperfusion injury. In humans, however, pharmacological interventions have so far failed to reduce myocardial reperfusion injury. We summarize the pathogenesis of reperfusion injury, detailing the role of fibrin(ogen) and its derivatives. Moreover, we introduce a new concept for fibrin derivatives as potential targets for reperfusion therapy.

Mentioned in this Paper

Ischemia
Pathogenic Aspects
Fibrin Measurement
Necrosis
Pathogenesis
Derivatives
Anti-Inflammatory Agents
Myocardial Dysfunction
Myocardium
Myocardial Infarction

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