Fibrinogen-bearing protein genes in the snail Biomphalaria glabrata: characterization of two novel genes and expression studies during ontogenesis and trematode infection.

Developmental and Comparative Immunology
Si-Ming ZhangRandall J Dejong

Abstract

All fibrinogen (FBG)-bearing proteins documented to date in the freshwater snail Biomphalaria glabrata, the intermediate host of the human blood fluke Schistosoma mansoni, possess the same molecular structure; one or two immunoglobin superfamily (IgSF) domains at the N-terminus and a FBG domain at the C-terminus (named as FBG-related protein (FREP)). Here we report two novel genes that encode FBG-bearing proteins from B. glabrata. Different from all known FREPs, the first gene encodes a protein (657 amino acids (aa)) composed of a long N-terminal region with no sequence homology to any known protein, a middle epidermal growth factor (EGF) repeat region and a C-terminal FBG domain, designated FBG-related molecule (FReM). Differential expression at 2 days post-exposure (dpe) to the trematode S. mansoni or Echinostoma paraensei was found in the S. mansoni susceptible M line and resistant BS-90 snail strains. The second gene is a new member of the FREP family, designated FREP14, which encodes a 399 aa putative secreted protein. FREP14 is different from known FREPs in that it is encoded by a single locus and is not upregulated in early or late stage S. mansoni exposure, but is upregulated in late stage E. paraensei infection. Furthe...Continue Reading

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Citations

Nov 11, 2010·Journal of Innate Immunity·Patrick C Hanington, Si-Ming Zhang
Dec 25, 2010·Developmental and Comparative Immunology·Julie GhoshL Courtney Smith
Dec 23, 2009·Developmental and Comparative Immunology·A M GorbushinN V Iakovleva
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Oct 23, 2016·Fish & Shellfish Immunology·Fujun HouXiaolin Liu
Mar 8, 2018·International Journal of Molecular Sciences·Weilin WangLinsheng Song

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