Fibrinogen-bound sialic acid levels in the dysfibrinogenaemia of liver disease

Haemostasis
J L Francis, D J Armstrong

Abstract

Fibrinogen-bound sialic acid levels were determined in 75 normal controls and 80 patients with liver disease. Patients with abnormal fibrin monomer polymerisation (FMP) had sialic acid levels significantly higher than controls or patients with normal FMP. Enzymatic removal of sialic acid from the abnormal fibrinogens corrected the abnormal FMP and thrombin-clotting times to the range of desialated controls. The accelerating effects of calcium ions, protamine sulphate and Polybrene were largely abolished by desialation, suggesting that these cations accelerate FMP by neutralising the negativity charged sialic acid residues.

Citations

May 1, 1984·Thrombosis Research·J L FrancisV J Simmonds
Oct 1, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yu-Min ShenStephen Brennan
Aug 12, 2009·Clinics in Laboratory Medicine·Valerie L Ng
Apr 5, 2012·American Journal of Hematology·Trailokya Nath Pandit, Ravindra Sarode
May 6, 2015·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A BienholzF H Saner
Dec 23, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Yasmin KamelKhaled Yassen

Related Concepts

Fibrinmonomer
Hereditary Factor I Deficiency Disease
Fibrin split products
Gamma-Fibrinogen
Fibrosis, Liver
Liver Dysfunction
Platelet Membrane Glycoproteins
Hormone Receptors, Cell Surface
Sialic Acids
Thrombin Time Assay

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