Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study

British Journal of Anaesthesia
O KarlssonM Hellgren

Abstract

Low plasma fibrinogen concentration has been linked to postpartum haemorrhage. The primary aim of this study was to assess whether fibrinogen concentration at admission before labour is associated with severe postpartum haemorrhage. Secondary aims were to describe fibrinogen concentration before and after labour and to identify predictors for severe postpartum haemorrhage. 1951 healthy women were included in a prospective observational study. Fibrinogen concentration was determined at admission to the labour ward and in a subgroup of women (n=80) also after the placenta was delivered. Bleeding volume postpartum was estimated by weighing surgical sponges and pads and by measuring collected blood. Predictors for severe postpartum haemorrhage (>1000 ml) were identified with bivariate and multivariate regression analyses. Mean fibrinogen concentration was 5.3 (SD 0.8) g litre(-) (1). Median estimated blood loss was 450 (range 70-4400) ml and 250 (12.8%) women bled >1000 ml. Fibrinogen concentration was not correlated with postpartum haemorrhage in the entire cohort (r(s)=0.003, P=0.90) or in any subgroup. Fibrinogen concentration was not associated with bleeding >1000 ml (odds ratio 1.01 (CI 95% 0.85-1.19), P=0.93) and did not diff...Continue Reading

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Citations

Feb 24, 2016·Archives of Gynecology and Obstetrics·Katja Niepraschk-von DollenFranziska Pauly
Dec 8, 2015·Hematology·Evelyn Lockhart
Jul 22, 2016·Journal of Perinatal Medicine·Lutz KaufnerChristian Bamberg
Aug 30, 2018·The Journal of Obstetrics and Gynaecology Research·Shigetaka MatsunagaHiroyuki Seki
Nov 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Laura E DodgeLynne Uhl
Dec 15, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Nalini MishraIshan Mishra
May 24, 2021·International Journal of Obstetric Anesthesia·O KarlssonM Hellgren

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