Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis

Molecular Medicine Reports
Yang ZhangJu-Hui Chen

Abstract

The protective role of fibrinogen‑like‑protein 1 (FGL1) in liver injury has been reported previously. However, there are few studies on FGL1 expression in gastric cancer (GC) tissues, and the role of FGL1 in GC remains unclear. The aim of the present study was to investigate the correlation between FGL1 expression and prognosis in GC patients. Data was downloaded from The Cancer Genome Atlas database, and 50 pairs of GC tissues and the corresponding non‑tumor tissues were collected between 2008 to 2011. Furthermore, FGL1 expression was silenced in order to explore its role in SGC‑7901 cell proliferation, invasion and migration using Cell Counting Kit‑8, wound healing, Transwell invasion and migration assays, respectively. Finally, whether FGL1 is involved in epithelial‑mesenchymal transition (EMT) regulation in SGC‑7901 cells was determined by western blotting. The results revealed that FGL1 expression was upregulated in GC tissues, and the overall survival time of GC patients with high FGL1 expression levels was markedly shorter than that of GC patients with low FGL1 expression levels (P=0.005). In addition, silencing FGL1 significantly inhibited SGC‑7901 cell proliferation, invasion and migration in vitro. Finally, western bl...Continue Reading

References

Jun 15, 1993·Biochemical and Biophysical Research Communications·T YamamotoS Hirohashi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 19, 2003·Nature Reviews. Molecular Cell Biology·Stefan GrünertHartmut Beug
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanae NakajimaMasayuki Imamura
Feb 17, 2007·International Journal of Cancer. Journal International Du Cancer·Ming-Tsan LinMin-Liang Kuo
Nov 28, 2007·Biochemical and Biophysical Research Communications·Zhilin Liu, Chinweike Ukomadu
Mar 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A E DassenJ W W Coebergh
Jun 4, 2011·Cellular and Molecular Life Sciences : CMLS·Arun Satelli, Shulin Li
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Oct 27, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Katrin M Sjoquist, John R Zalcberg
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Aug 1, 2015·Biochemical and Biophysical Research Communications·Hamed Nayeb-HashemiChinweike Ukomadu
May 24, 2016·Journal of Hepatology·Gianluigi GiannelliWolfgang Mikulits
Dec 15, 2017·Journal of Cancer Research and Therapeutics·Xinping XieLihong Chen

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Methods Mentioned

BETA
RNA-Seq
transfection

Software Mentioned

SPSS
Quantity One

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