PMID: 2508383Apr 1, 1989Paper

Fibrinolysis and spinal injury. Relationship to post-traumatic deep vein thrombosis

Acta Chirurgica Scandinavica
J PetäjäM Nokelainen

Abstract

Tissue plasminogen activator (t-PA) activity and antigen (t-PA:Ag) at rest and after venous occlusion (VO), were measured on admission to hospital in 9 patients with acute spinal cord injury (SCI) (group P) and in 12 patients who were immobilized due to a fracture of the cervical spine without paralysis (group C). In addition, the levels of t-PA:Ag, t-PA activity, t-PA inhibitor activity (PAI), the von Willebrand factor (vWF:Ag), F VIII:C and fibrinogen were monitored until the 10th post-traumatic day. Venous thrombosis (VT) was detected by the 125I-labelled fibrinogen test in 78% in group P and in 8% in group C. The median t-PA activity after VO was 8.6 IU/ml and 41.6 IU/ml in groups P and C, respectively (p less than 0.01). The t-PA:Ag increased similarly during VO in both groups and reached a level of 55.0 ng/ml in group P and 64.9 ng/ml in group C. The median level of PAI activity before VO was 19.2 U/ml in group P and 15.8 U/ml in group C. The trend of higher PAI values in group P than in C was more pronounced after VO (13.4 U/ml vs. 2.0 U/ml). High individual levels of PAI were found during the first 72 h of immobilization in both group P and group C. The levels of vWF:Ag and fibrinogen were significantly higher in group ...Continue Reading

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.