Fibrinolysis in critically ill patients

The American Review of Respiratory Disease
R MoalliT Saldeen


Impaired fibrinolysis may contribute to development of adult respiratory distress syndrome (ARDS). Pathologic increases in endogenous plasminogen activator inhibitor (PAI-1) may blunt normal fibrinolysis and unmask alternate fibrinolytic mechanisms, such as elastase-induced fibrin degradation. We measured PAI-1 and elastase-induced fibrin(ogen) degradation products in 69 critically ill patients in our medical intensive care unit (MICU) and in nine healthy volunteers. Factor VIII-related antigen protein (VIII:Ag), a reported marker of acute lung injury, and alpha-1-protease inhibitor (alpha-1-PI), an acute phase reactant, were also measured. MICU patients included 24 control patients with no known risk of ARDS, 35 patients with risk factors for ARDS including sepsis, pneumonia, aspiration, and shock, and 12 patients with ARDS including two patients from at-risk groups who developed ARDS. Plasma PAI-1 was determined by chromogenic assay, elastase-induced peptides by a new radioimmunoassay, VIII:Ag by immunoelectrophoresis, and alpha-1-PI by immunodiffusion. When compared to normal volunteers, MICU control patients had elevated PAI-1, VIII:Ag, elastase-induced peptides, and alpha-1-PI. Patients with ARDS had significantly higher P...Continue Reading

Associated Clinical Trials


Jul 1, 1975·The Journal of Clinical Investigation·E F Plow, T S Edgington
Nov 9, 1978·The New England Journal of Medicine·J O Morse
Nov 1, 1976·The American Journal of Medicine·R C BoneA K Pierce
Oct 28, 1982·The New England Journal of Medicine·A CarvalhoW M Zapol
Jan 27, 1983·Biochemical and Biophysical Research Communications·J J EmeisG Wijngaards
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E G Levin
Jan 1, 1982·Annals of the New York Academy of Sciences·T Saldeen
Jan 1, 1982·Annals of the New York Academy of Sciences·K H Berecek, M J Brody
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers


Apr 12, 2003·Critical Care Medicine·Steven Idell
Feb 3, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Heidi FloriMichael A Matthay
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Lorraine B WareMichael A Matthay
Jun 24, 2005·Respiratory Research·Argyris TzouvelekisDemosthenes Bouros
Oct 21, 2005·The Keio Journal of Medicine·Lorraine B WareLing Wang
Jun 1, 1996·Clinics in Chest Medicine·P E Parsons, M Moss
Jan 1, 1994·Chest·N HasegawaT A Raffin
Apr 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Christine L LauDavid J Pinsky
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·David ShitritMoshe Hersch
Jun 3, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anil SapruPediatric Acute Lung Injury Consensus Conference Group
Dec 4, 2013·Current Opinion in Critical Care·Alexandra BinnieClaudia C dos Santos
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R T SchermulyD Walmrath
Jan 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Russell P BowlerMark W Duncan
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yuval ShilonDavid Shitrit
Jan 25, 2019·Journal of Inflammation·Savino SpadaroCarlo Alberto Volta
Jan 1, 2021·International Journal of Molecular Sciences·Pradeesh SivapalanJens-Ulrik Jensen
Mar 16, 2021·Anesthesiology·Grace HoganGerard F Curley

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.