Fibrinolysis in critically ill patients

The American Review of Respiratory Disease
R MoalliT Saldeen

Abstract

Impaired fibrinolysis may contribute to development of adult respiratory distress syndrome (ARDS). Pathologic increases in endogenous plasminogen activator inhibitor (PAI-1) may blunt normal fibrinolysis and unmask alternate fibrinolytic mechanisms, such as elastase-induced fibrin degradation. We measured PAI-1 and elastase-induced fibrin(ogen) degradation products in 69 critically ill patients in our medical intensive care unit (MICU) and in nine healthy volunteers. Factor VIII-related antigen protein (VIII:Ag), a reported marker of acute lung injury, and alpha-1-protease inhibitor (alpha-1-PI), an acute phase reactant, were also measured. MICU patients included 24 control patients with no known risk of ARDS, 35 patients with risk factors for ARDS including sepsis, pneumonia, aspiration, and shock, and 12 patients with ARDS including two patients from at-risk groups who developed ARDS. Plasma PAI-1 was determined by chromogenic assay, elastase-induced peptides by a new radioimmunoassay, VIII:Ag by immunoelectrophoresis, and alpha-1-PI by immunodiffusion. When compared to normal volunteers, MICU control patients had elevated PAI-1, VIII:Ag, elastase-induced peptides, and alpha-1-PI. Patients with ARDS had significantly higher P...Continue Reading

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References

Jul 1, 1975·The Journal of Clinical Investigation·E F Plow, T S Edgington
Nov 9, 1978·The New England Journal of Medicine·J O Morse
Nov 1, 1976·The American Journal of Medicine·R C BoneA K Pierce
Oct 28, 1982·The New England Journal of Medicine·A C CarvalhoW M Zapol
Jan 27, 1983·Biochemical and Biophysical Research Communications·J J EmeisG Wijngaards
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E G Levin
Jan 1, 1982·Annals of the New York Academy of Sciences·T Saldeen
Jan 1, 1982·Annals of the New York Academy of Sciences·K H Berecek, M J Brody
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers

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Citations

Apr 12, 2003·Critical Care Medicine·Steven Idell
Feb 3, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Heidi R FloriMichael A Matthay
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Lorraine B WareMichael A Matthay
Jun 24, 2005·Respiratory Research·Argyris TzouvelekisDemosthenes Bouros
Oct 21, 2005·The Keio Journal of Medicine·Lorraine B WareLing Wang
Jun 1, 1996·Clinics in Chest Medicine·P E Parsons, M Moss
Jan 1, 1994·Chest·N HasegawaT A Raffin
Apr 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Christine L LauDavid J Pinsky
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·David ShitritMoshe Hersch
Jun 3, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anil SapruUNKNOWN Pediatric Acute Lung Injury Consensus Conference Group
Dec 4, 2013·Current Opinion in Critical Care·Alexandra BinnieClaudia C dos Santos
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R T SchermulyD Walmrath
Jan 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Russell P BowlerMark W Duncan
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yuval ShilonDavid Shitrit
Jan 25, 2019·Journal of Inflammation·Savino SpadaroCarlo Alberto Volta
Jan 1, 2021·International Journal of Molecular Sciences·Pradeesh SivapalanJens-Ulrik Jensen
Mar 16, 2021·Anesthesiology·Grace HoganGerard F Curley
Dec 17, 2009·The American Journal of the Medical Sciences·Iraklis TsangarisApostolos Armaganidis

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