PMID: 9194761Jun 1, 1997Paper

Fibrinolytic activity is similar in physically active men with and without a history of myocardial infarction

Arteriosclerosis, Thrombosis, and Vascular Biology
B FernhallC M Kessler

Abstract

The purpose of this study was to evaluate fibrinolytic potential at rest and after a fibrinolytic stressor in men with a history of myocardial infarction (MI) compared with an age- and activity-matched group of men without coronary artery disease (CAD). All men were currently enrolled in exercise programs. Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor 1 (PAI-1) activity and antigen levels were measured at rest and after a maximal exercise test. A 2 x 2 (group x time) ANOVA with repeated measures was used to evaluate fibrinolytic potential. Bivariate regressions were conducted to evaluate relations between fibrinolytic potential and maximal oxygen uptake (VO2max). Age was similar between groups (CAD, 57.5 +/- 6.6; non-CAD, 58.1 +/- 7.3 years); however, VO2max was higher in non-CAD subjects (36.2 +/- 6.2 vs 27.5 +/- 5.9 mL.kg-1.min-1). Mean +/- SEM resting TPA and PAI-1 activities were similar between CAD and non-CAD subjects (TPA, 2.8 +/- 0.2 vs 2.8 +/- 0.2 IU/mL; PAI-1, 15.9 +/- 3.1 vs 13.1 +/- 4.1 AU/mL). Both groups showed similar significant increases in TPA activity with exercise (P < .05), and postexercise TPA activity was also similar (CAD, 9.1 +/- 2.0 IU/mL; non-CAD, 11.7 +/- 2.6 IU/mL). Bot...Continue Reading

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Citations

Feb 16, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Bjarne Madsen HärdigS Bertil Olsson
Oct 16, 1999·American Journal of Obstetrics and Gynecology·R OtterstetterB Fernhall
Jun 28, 2001·Medicine and Science in Sports and Exercise·R RauramaaS B Väisänen

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