Fibrinolytic dysfunction in insulin-resistant women with previous gestational diabetes

European Journal of Clinical Investigation
S FarhanAlexandra Kautzky-Willer

Abstract

Women with a history of gestational diabetes (p-GDM) are at increased risk of developing type 2 diabetes mellitus (DM2) later in life, and therefore at increased risk for future cardiovascular disease. Three months after delivery we investigated the plasma levels of plasminogen activator inhibitor type 1 (PAI-1), tissue plasminogen activator (t-PA), fibrinogen and von Willebrand factor (vWF) in 74 women with p-GDM and 20 healthy females with normal glucose tolerance during and after pregnancy, as well as the relation of fibrinolytic parameters to insulin resistance and glycaemic control. All women underwent an oral (OGTT) as well as an intravenous glucose tolerance test (FSIGT). Mathematical model analysis disclosed that 50% (n=37 each) of the p-GDM subjects had normal (NIS) or impaired (IIS) insulin sensitivity. Parameters of interest were determined using commercially available test systems. Women with p-GDM and IIS had significantly increased body fat mass (BFM) (P<or=0.001) compared with women with p-GDM and NIS and controls, whereas the waist to hip ratio (WHR) was similar in both p-GDM groups but was higher compared with the controls (P<or=0.001). Mean PAI-1 and t-PA as well as fasting and stimulated plasma concentrations...Continue Reading

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Citations

Mar 17, 2010·Wiener medizinische Wochenschrift·Serdar FarhanKurt Huber
Sep 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Lynn P LoweUNKNOWN HAPO Study Cooperative Research Group
Dec 18, 2013·Women's Health·Jürgen HarreiterAlexandra Kautzky-Willer
Apr 21, 2012·International Journal of Endocrinology·Nikolaos VrachnisGeorge Creatsas
Aug 30, 2008·Diabetes Research and Clinical Practice·Baris AkinciSena Yesil
Jun 6, 2009·European Journal of Clinical Investigation·A Kautzky-Willer, A Handisurya
Dec 22, 2006·European Journal of Clinical Investigation·S GasicA Kautzky-Willer
Mar 17, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Baris AkinciSena Yesil
Aug 2, 2017·International Journal of Molecular Sciences·Yao YeViktoria von Schönfeldt
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Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Feb 27, 2008·Diabetes Care·John L KitzmillerM Mark Taslimi

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