Fibrinolytic responses to 1-desamino-8-D-arginine-vasopressin in patients with congenital nephrogenic diabetes insipidus

Nephron
N KnoersL A Monnens

Abstract

Fibrinolytic responses to infusion of 1-desamino-8-D-arginine-vasopressin (DDAVP) were assessed in 6 males with congenital nephrogenic diabetes insipidus (NDI), 6 carriers of the NDI gene and 6 normal control subjects. Tissue-type plasminogen activator (t-PA) activity and antigen increased significantly in normal subjects, while plasminogen activator inhibitor (PAI) activity decreased. None of these changes were observed in patients with NDI. In 2 female carriers, normal fibrinolytic responses were seen, while in the other carriers responses were delayed. These findings are consistent with the concept of a general V2-receptor defect in congenital NDI. DDAVP tests are of limited use in NDI carrier detection.

Citations

Oct 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N KnoersB A van Oost
Sep 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N Knoers, L A Monnens
Mar 1, 1991·European Journal of Pediatrics·N Knoers, L A Monnens
Dec 29, 2000·Current Opinion in Nephrology and Hypertension·P M DeenB W van Balkom
May 1, 1992·European Journal of Pediatrics·N KnoersL A Monnens
Nov 20, 1998·The American Journal of the Medical Sciences·P M Deen, N V Knoers
Jun 4, 2008·Seminars in Nephrology·Anne J M LoonenPeter M T Deen
Dec 1, 1994·Trends in Endocrinology and Metabolism : TEM·N V Knoers
Jul 11, 2006·American Journal of Physiology. Renal Physiology·Joris H RobbenPeter M T Deen

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