Fibrinolytic responses to acute physical activity in older hypertensive men

Journal of Applied Physiology
C A DeSouzaR F Macko

Abstract

We tested the hypothesis that the fibrinolytic response to acute physical activity is impaired in sedentary older hypertensive men, which may contribute to the risk of exertion-triggered acute myocardial infarction in this population. Tissue-type plasminogen activator (t-PA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) antigen and activity were measured in 12 hypertensive (69 +/- 1 yr) and 11 normotensive (64 +/- 1 yr) men before and after an acute bout of submaximal exercise. Contrary to our hypothesis, there were no differences between the two groups in the fibrinolytic response to exercise. t-PA antigen and activity were significantly elevated in both the hypertensive (38 and 172%, respectively) and normotensive (45 and 130%, respectively) groups immediately after exercise but they returned to resting levels within 30 min. There was no change in PAI-1 antigen levels immediately after exercise in either group; however, PAI-1 antigen was significantly lower at 30 and 60 min postexercise in both the hypertensive (31 and 16%, respectively) and normotensive (35 and 20%, respectively) groups. PAI-1 activity was significantly lower immediately after exercise in both the hypertensive (25%) and normotensive (22%...Continue Reading

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Citations

Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M Cesari, G P Rossi
Jun 28, 2001·Medicine and Science in Sports and Exercise·R RauramaaS B Väisänen
Jan 28, 2003·Journal of Neuroscience Research·Xi JiangJames O'Rourke
Feb 17, 2017·Drug Discoveries & Therapeutics·Hideo Ikarugi, Junichiro Yamamoto
Feb 6, 2003·Medicine and Science in Sports and Exercise·Frederick M IveyRichard F Macko
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L CoppolaG Gombos
Nov 22, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Kathleen Menzel, Thomas Hilberg
May 4, 2015·Human Reproduction Update·Chelsea N FortinMichael P Diamond
Nov 25, 2003·Obesity Research·Penelope J MorrisNicholas Finer
Nov 2, 2014·American Journal of Hypertension·Eugenia GkaliagkousiStella Douma
Sep 7, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Charalampos I LiakosChristodoulos I Stefanadis
Nov 28, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Vassiliki GaleaJohn Lekakis
Sep 4, 2020·Seminars in Thrombosis and Hemostasis·Emma Kate ZadowBrett Ashley Gordon

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