Fibro-porous meshes made from polyurethane micro-fibers: effects of surface charge on tissue response

Biomaterials
J E SandersBuddy D Ratner

Abstract

The purpose of this research was to evaluate the influence of surface charge on fibrous encapsulation, cell nuclei density, and vessel ingrowth into small-fiber, fibro-porous, biomaterial meshes. Meshes electrospun from polyurethane with mean fiber diameters of 5.8 microm and mean fiber spacing of 64.9 microm were plasma coated with films of different relative surface charge: Hexafluoropropylene (HF) (neutral), N,N-dimethylaminoethyl methacrylate (NN) (positive charge), and methacrylic acid (MA) (negative charge). Samples were implanted in rat subcutaneous dorsum for 5 weeks then fibrous capsule presence around the implants, cell nuclei density, and vessel number were assessed. Results showed that within the resolution of the histological analysis methods used, no implant experienced fibrous encapsulation. There was no significant difference between cell nuclei density and coating for the four groups: uncoated, HF-coated, NN-coated, and MA-coated. HF-coated and NN-coated samples had lower vessel numbers than uncoated samples (p = 0.055 and 0.032, respectively). MA-coated samples had vessel numbers not significantly different from uncoated polyurethane (slightly negatively charged) samples (p = 0.879). The results suggest that n...Continue Reading

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Citations

Mar 2, 2005·Tissue Engineering·Zuwei MaSeeram Ramakrishna
Mar 24, 2009·Colloids and Surfaces. B, Biointerfaces·David R NisbetWei Shen
Jan 26, 2012·Journal of Biomedical Materials Research. Part a·M MoczulskaA Bruinink
May 15, 2012·Journal of Biomedical Materials Research. Part a·Riteshkumar J Patel, Michael V Sefton
Oct 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kristan S WorthingtonEric Nuxoll
Nov 26, 2010·IEEE Transactions on Bio-medical Engineering·Eli VlaisavljevichRupak M Rajachar
Nov 18, 2005·Biomaterials·Jian YangGuillermo A Ameer
Jul 28, 2006·Nanotechnology·W E Teo, S Ramakrishna
May 23, 2006·Pharmacological Reviews·Ajit S Narang, Ram I Mahato
Dec 28, 2019·International Journal of Molecular Sciences·Nopphadol UdomluckHansoo Park
Jul 10, 2017·ACS Biomaterials Science & Engineering·Greeshma RatheeshSeeram Ramakrishna

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