Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival

British Journal of Haematology
Yun GeShmuel Yaccoby

Abstract

The microenvironment plays a critical role in facilitating cancer progression and metastasis. We previously demonstrated the ability of osteoclasts to support primary myeloma plasma cell (MM PC) growth. Our study on the role of the bone marrow (BM) microenvironment in myeloma, using global gene expression profiling, has identified fibroblast activation protein (FAP) as one of 28 genes significantly overexpressed in cocultured osteoclasts. Because FAP has been previously implicated in tumorigenesis and shown to be selectively expressed by the reactive stroma of epithelial tumours, we focused our study on the role of this serine protease in myeloma. Using quantitative polymerase chain reaction amplification, we demonstrated upregulation of FAP by cocultured osteoclasts and mesenchymal stem cells, and in whole myelomatous human bone in SCID-hu mice. Immunohistochemical analysis of myelomatous bone sections revealed FAP expression by osteoclasts, osteogenic cells, fibrotic stroma and certain adipocytes and vascular endothelial cells. FAP was not expressed in PCs by all these methods. Inhibition of FAP expression with the use of small-interference RNA reduced MM PC survival in cocultures. Our results indicate that FAP is critical fo...Continue Reading

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Garin-ChesaW J Rettig
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W J RettigL J Old
Aug 24, 1999·The Journal of Biological Chemistry·S C MuellerW T Chen
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·R N PearseY Choi
May 25, 2002·The Journal of Biological Chemistry·Giulio GhersiWen-Tien Chen
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Oct 24, 2002·Blood·Shmuel YaccobyJoshua Epstein
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G David Roodman
Nov 26, 2002·Hematology·Kenneth C AndersonG David Roodman
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter I CroucherKarin Vanderkerken
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Roderick J PhillipsRobert M Strieter
Apr 17, 2003·Current Topics in Developmental Biology·Wen-Tien ChenGiulio Ghersi
May 10, 2003·Cancer Treatment Reviews·William S Dalton
Jun 26, 2003·British Journal of Haematology·Franco SilvestrisFranco Dammacco
Aug 28, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·K FalkL Holmdahl
Sep 23, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Joshua Epstein, Shmuel Yaccoby
Nov 6, 2003·Clinical Orthopaedics and Related Research·Regis J O'Keefe, Theresa A Guise
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Mar 9, 2004·Blood Cells, Molecules & Diseases·G David Roodman
Mar 18, 2004·Cancer Research·Shmuel YaccobyJoshua Epstein
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
May 11, 2004·Oncogene·Teresa Ramirez-MontagutAlan N Houghton
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Darash-YahanaAmnon Peled
Jun 9, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Thomas Kelly
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shmuel Yaccoby

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Citations

Feb 9, 2012·Clinical and Experimental Medicine·Dongfeng ZengPeiyan Kong
Dec 23, 2006·Cancer Metastasis Reviews·Rosandra N KaplanDavid Lyden
Feb 3, 2012·Journal of Bioenergetics and Biomembranes·Ayako NakanoMasahiro Abe
Jun 24, 2011·International Journal of Hematology·Qu CuiMasahiro Abe
Oct 19, 2011·International Journal of Hematology·Masahiro Abe
Jan 1, 2012·BoneKEy Reports·Deborah L GalsonG David Roodman
Apr 26, 2008·Blood·Xin LiShmuel Yaccoby
Nov 12, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Paulette Mhawech-FaucegliaTanja Pejovic
Apr 13, 2012·Cancer Treatment Reviews·Vito LongoFranco Silvestris
Sep 1, 2007·British Journal of Haematology·Xin LiShmuel Yaccoby
Mar 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xin LiShmuel Yaccoby
Mar 17, 2010·British Journal of Haematology·Shmuel Yaccoby
Apr 6, 2007·Biochemical and Biophysical Research Communications·Bo SunKyung-Sun Kang
Jun 15, 2007·International Reviews of Immunology·Maurizio Chiriva-InternatiW Martin Kast
Jan 13, 2018·British Journal of Haematology·Shiro FujiiMasahiro Abe
Nov 21, 2019·Clinical and Experimental Medicine·Liang ZhangKai Wang
Dec 28, 2006·Neurochemical Research·Lianhua BaiRobert H Miller
Jul 1, 2020·Cancer Metastasis Reviews·Allison A Fitzgerald, Louis M Weiner
Jun 1, 2021·PET Clinics·Katharina DendlFrederik L Giesel
Sep 28, 2017·Journal of Medicinal Chemistry·Petra DvořákováJan Konvalinka

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