Fibroblast-Cytophilic and HeLa-Cytotoxic Dual Function Carbon Nanoribbon Network Platform

ACS Applied Materials & Interfaces
A K M Rezaul Haque ChowdhuryK Venkatakrishnan

Abstract

Carbon nanomaterials have emerged as a promising material in cancer diagnosis and therapy. Carbon nanomaterials/nanostructures (C-C molecular structure) act as a carrier/skeleton and require further surface modification through functionalization with chemicals or biomolecules to attain cell response. We report the synthesis of a novel carbon nanoribbon network (CNRN) platform that possesses a combination of C-C and C-O bond architecture. The bioactive CNRN showed enhanced ability for cell adhesion. Most importantly, it induced opposite cell responses from healthy cells and cancerous cells, cytophilic to fibroblasts but cytotoxic to HeLa cells. Ultrafast laser ionization under ambient conditions transforms nonbioresponsive C-C bond of graphite to C-C and C-O bonds, forming a self-assembled CNRN platform. The morphology, nanochemistry, and functionality on modulating fibroblast and HeLa adhesion and proliferation of the fabricated CNRN platforms were investigated. The results of in vitro studies suggested that the CNRN platforms not only attracted but also actively accelerated the adhesion and proliferation of both fibroblasts and HeLa cells. The proliferation rate of fibroblasts and HeLa cells is 91 and 98 times greater compared...Continue Reading

References

Dec 18, 2002·Physical Review Letters·Danny Perez, Laurent J Lewis
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Kyung Mi WooPeter X Ma
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Oct 16, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Stephanie Reich, Christian Thomsen
Nov 16, 2006·Journal of the American Chemical Society·Igor SlowingVictor S-Y Lin
Mar 10, 2007·Physical Chemistry Chemical Physics : PCCP·M A PimentaR Saito
Nov 30, 2007·Biophysical Journal·Jérôme SolonPaul A Janmey
Dec 7, 2007·The Journal of Cell Biology·Jonathan D HumphriesChristoph Ballestrem
Sep 6, 2008·Nature Nanotechnology·Adam De la ZerdaSanjiv S Gambhir
Jan 23, 2009·Optics Express·Bo Tan, Krishnan Venkatakrishnan
Apr 7, 2009·The Journal of Physical Chemistry. B·Youliang HongXingdong Zhang
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Feb 13, 2010·Biomaterials·Guillaume LamourAhmed Hamraoui
May 4, 2010·Biochimica Et Biophysica Acta·Andrea KunzmannBengt Fadeel
Jan 18, 2011·Colloids and Surfaces. B, Biointerfaces·A Dolatshahi-PirouzF Besenbacher
Jun 10, 2011·ACS Applied Materials & Interfaces·Ken-Hsuan LiaoChristy L Haynes
Dec 31, 2011·Biomaterials·Ganesh Gollavelli, Yong-Chien Ling
Apr 25, 2012·Annual Review of Biomedical Engineering·Alexandre AlbaneseWarren C W Chan
May 1, 2012·Journal of Cell Science·Sari TojkanderPekka Lappalainen
Jun 19, 2012·Journal of Biomedical Materials Research. Part a·Marie KalbacovaMartin Kalbac
Aug 16, 2012·Accounts of Chemical Research·Motao ZhuYuliang Zhao
Oct 18, 2012·Biomaterials·Sayan Mullick ChowdhuryBalaji Sitharaman
Dec 12, 2012·Tissue Engineering. Part a·Shimon BenjaminZulma Gazit
Jan 11, 2013·Journal of the American Chemical Society·Anna LesniakChristoffer Åberg
Jan 30, 2013·Journal of Photochemistry and Photobiology. B, Biology·X C QinB W Yang
Oct 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sumit GoenkaShilpa Sant
Nov 2, 2013·Journal of Biomedical Materials Research. Part a·Ashkan AryaeiAmbalangodage C Jayasuriya
Nov 28, 2013·Chemical Reviews·Lev A Dykman, Nikolai G Khlebtsov
Mar 29, 2014·Biomaterials·Yahfi TalukdarBalaji Sitharaman
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Patricia A SantosMauricio S Baptista
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Raluca IonGheorghe Dinescu
Jun 16, 2015·ACS Applied Materials & Interfaces·James Throckmorton, Giuseppe Palmese
Aug 11, 2015·ACS Nano·Sulin ZhangGang Bao
Apr 2, 2016·ACS Applied Materials & Interfaces·Amirhossein TavangarKrishnan Venkatakrishnan
Dec 1, 2011·Nanoscale Research Letters·Kan WangDaxiang Cui

❮ Previous
Next ❯

Citations

Aug 24, 2018·Canadian Journal of Physiology and Pharmacology·Rajesh Lakshmanan, Nilanjana Maulik
Sep 21, 2019·Future Medicinal Chemistry·Giuseppe CirilloSilke Hampel
Oct 28, 2019·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Harshita PandeyShiv Singh
Sep 29, 2018·ACS Applied Materials & Interfaces·A K M Rezaul Haque ChowdhuryKrishnan Venkatakrishnan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.