Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Endocrine Journal
Su WangGuoyue Yuan

Abstract

Fibroblast growth factor 1 (FGF1) has been recently characterized as a potent insulin sensitizer that regulates adipose tissue remodeling, but the physiological role of FGF1 remains unclear. This study measured serum FGF1 levels for the first time in patients with newly diagnosed type 2 diabetes mellitus (T2DM), and further explored the correlations between FGF1 levels and various metabolic parameters in T2DM. Serum FGF1 levels were determined using ELISA in age-, sex- and BMI- matched subjects with normal glucose tolerance (NGT) (n=80) and newly diagnosed T2DM (n=80). Oral glucose tolerance test (OGTT), glycosylated hemoglobin (HbA1C), blood lipids, and insulin secretion were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of beta cell function (HOMA-β), respectively. Serum FGF1 levels were significantly higher in T2DM patients than in normal glucose tolerance subjects (74.52 [55.91∼101.34] vs. 60.31 [48.99∼83.91] pg/mL; P<0.05). In addition, serum FGF1 level positively correlated with body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), fasting plasma glucose (FPG), 2-h post-OGT...Continue Reading

References

Jun 21, 1996·The Journal of Biological Chemistry·D M OrnitzM Goldfarb
Nov 25, 2004·Diabetes·Louise HutleyJohannes Prins
Oct 28, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Felicity S NewellLouise J Hutley
Sep 6, 2007·Journal of Cellular Biochemistry·Igor PrudovskyThallapuranam Krishnaswamy Suresh Kumar
Oct 23, 2008·American Journal of Physiology. Endocrinology and Metabolism·C H WidbergJ B Prins
Jan 19, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Farhad MashayekhiMohammad Naji
Mar 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Niklas MejhertMikael Rydén
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Jun 24, 2011·Endocrine, Metabolic & Immune Disorders Drug Targets·Hiroya OhtaNobuyuki Itoh
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Jan 15, 2014·Diabetes Research and Clinical Practice·Juliana C N ChanJonathan Shaw
Mar 8, 2014·Frontiers in Endocrinology·Hiroya Ohta, Nobuyuki Itoh
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
May 16, 2014·Journal of Signal Transduction·Rajesh RajuHarsha Gowda
Jul 22, 2014·Nature·Jae Myoung SuhRonald M Evans
Dec 6, 2014·Trends in Endocrinology and Metabolism : TEM·Bryn M OwenSteven A Kliewer
Apr 29, 2015·Nature Communications·Rachel J PerryGerald I Shulman

❮ Previous
Next ❯

Citations

Aug 23, 2018·Metallomics : Integrated Biometal Science·Amélie I S SobczakAlan J Stewart
Apr 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Amélie I S SobczakAlan J Stewart
Jul 12, 2018·Endocrine Connections·Anru WangXiaoping Luo
Oct 10, 2018·Endocrine Connections·Anru WangXiaoping Luo
Nov 24, 2020·The Cell Surface·Michael J CohenPeter N Lipke
Feb 28, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hasibullah HabibiHiroaki Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Related Papers

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Yuhuan WangXuan Xie
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Ling LiK Li
© 2021 Meta ULC. All rights reserved