PMID: 9548179Apr 21, 1998Paper

Fibroblast growth factor-2 and fibroblast growth factor receptor-1 mRNA expression and peptide localization in placentae from normal and diabetic pregnancies

Placenta
E Arany, D J Hill

Abstract

Fibroblast growth factor-2 (FGF-2) is a potent mitogen expressed widely during embryogenesis and in tissues of the human fetus. It is recognized as an endothelial cell mitogen and is angiogenic in vivo. Expression of FGF-2 mRNA has also been shown within the human term placenta, and FGF-2 isolated from placental tissue, suggesting a role in placental growth including angiogenesis. The purpose of this study was to quantify and localize the sites of expression of FGF-2 and its high-affinity receptor, FGFR1, within placentae from normal term human pregnancies (n=8, 39-42 weeks), and pregnancies complicated by pregestational, type 1 diabetes (n=8, 36-40 weeks). Tissues were collected immediately following delivery and were either snap-frozen for RNA isolation, or fixed for either in situ hybridization using a 35S-labelled cRNAs encoding human FGF-2 or FGFR1, or immunocytochemistry using antibodies against human FGF-2 or FGFR1. Northern blot hybridization showed a significantly increased abundance of mRNAs for both FGF-2 and FGFR1 in placentae from diabetic women compared to those from normal women. In normal term placenta FGF-2 mRNA was present at low abundance in fetal villous tissue, in the vascular endothelium of blood vessels, ...Continue Reading

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Citations

Nov 3, 2001·Journal of Hepatology·K KanetakaS Hirohashi
Mar 1, 2000·Clinical Obstetrics and Gynecology·J Uvena-Celebrezze, P M Catalano
Jun 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Elena GianettiStephanie B Seminara
Feb 7, 2016·Médecine sciences : M/S·Anne GaboryAnne Tarrade
Mar 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal Y AntebySimcha Yagel
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Nov 4, 2017·Journal of Molecular Endocrinology·Yingchun LiEmily J Su
Oct 20, 2020·The Journal of Experimental Medicine·Jake R ThomasNaomi McGovern
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Feb 27, 2008·Diabetes Care·Gernot Desoye, Sylvie Hauguel-de Mouzon

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