Fibroblast growth factor-2 enhances extinction and reduces renewal of conditioned fear.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Bronwyn M Graham, Rick Richardson

Abstract

Anxiety disorders are increasingly prevalent in society; hence, there is a need to improve on existing treatments for such disorders. Fibroblast growth factor-2 (FGF2), a mitogen that is involved in brain development and regeneration, has been shown to both facilitate long-term extinction of fear and reduce stress-precipitated relapse in rats. Extinction is the laboratory analog of exposure-based therapies in humans. In this study, we continued to investigate the clinical potential of FGF2 as a pharmacological enhancer of extinction by examining its effect on renewal, a common type of relapse. In all experiments, rats were trained to fear a white noise-conditioned stimulus, and then this learned fear was extinguished the following day. Rats received systemic injections of FGF2 or vehicle immediately after extinction training. At test, on the day after extinction training, levels of freezing elicited by the white noise in either the extinction context or the original training context were measured. FGF2-treated rats showed less renewal of fear when tested in the original training context than did vehicle-treated rats. This pattern occurred even when vehicle rats were given double the amount of extinction training, and when FGF2-...Continue Reading

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Citations

Oct 20, 2011·Nature Communications·Charlotte R FlavellJonathan L C Lee
Dec 14, 2011·The Journal of Biological Chemistry·Sayaka OnoChihiro Sato
Jun 22, 2013·Journal of Biochemistry·Chihiro Sato, Ken Kitajima
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Aug 31, 2020·Molecular Aspects of Medicine·Chihiro Sato, Ken Kitajima
Jan 15, 2011·Learning & Memory·Bronwyn M Graham, Rick Richardson

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Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Bronwyn M Graham, Rick Richardson
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