PMID: 9436785Jan 22, 1998Paper

Fibroblast growth factor 2 (FGF-2) differentially regulates connexin (cx) 43 expression and function in astroglial cells from distinct brain regions

Glia
B ReussK Unsicker

Abstract

Fibroblast growth factor (FGF)-2 is a peptide growth factor that promotes the generation, differentiation, and survival of neurons and glial cells. In the CNS, astroglial cells are coupled in a region-specific manner by gap junctions consisting of connexin 43 (cx43). In the present study we have investigated effects of FGF-2 and of other growth factors on the expression and function of cx43 in astroglial cells cultured from telencephalic cortex, striatum, and mesencephalon of newborn rats. Confluent cultures were maintained for two days in low serum, and then exposed to FGF-2 (10 ng/ml) for 48 h. FGF-2 caused a reduction of cx43-protein, -mRNA, and intercellular communication revealed by dye spreading. These changes occurred in cortical and striatal cells, but not in mesencephalic astroglial cells. Effects of FGF-2 were time- and concentration-dependent, with a minimal effective dose of 1 ng/ml FGF-2, and an onset of effects after 6 h of incubation. The reduction of coupling by FGF-2 was transient, since in cortical and striatal cultures coupling recovered to control levels 48 h after removal of the growth factor. Like FGF-2, transforming growth factor-beta3 (TGF-beta3) decreased coupling of cortical and striatal, but not mesen...Continue Reading

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 1, 1990·Trends in Neurosciences·G P WilkinA J Cholewinski
Jan 1, 1992·Experimental Cell Research·L S SteinR C Burghardt
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D ZhuC C Naus
Jan 1, 1989·Annual Review of Pharmacology and Toxicology·D M Chuang
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R DermietzelK Willecke
Dec 1, 1987·The Journal of Cell Biology·E C BeyerD A Goodenough
Dec 1, 1988·The Journal of Membrane Biology·P E MaldonadoW R Loewenstein
Sep 9, 1985·FEBS Letters·B PettmannG Labourdette
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Aug 1, 1981·Developmental Biology·S J TapscottH Holtzer
Dec 1, 1994·Analytical Biochemistry·A W Henkel, S C Bieger
Mar 1, 1995·Journal of Neuroscience Research·J Garcia-AbreuL A Cavalcante
Feb 15, 1995·Journal of Neuroscience Research·Y J HouV K Menon
Jul 1, 1994·Brain Pathology·L F Eng, R S Ghirnikar
Feb 9, 1996·Cell·N M Kumar, N B Gilula
Feb 1, 1996·Experimental Neurology·S B WirthK Unsicker
May 1, 1996·Brain Research. Molecular Brain Research·M K StachowiakE K Stachowiak
Feb 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B ReussE Winterhager

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Citations

Mar 23, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eliseo A EugeninJoan W Berman
Mar 19, 2013·Neuropharmacology·Juan A OrellanaMauricio A Retamal
Oct 24, 2002·Brain Research·Doug Lobner, Carine Ali
Aug 15, 2002·Neurochemistry International·M M Fróes, J R L Menezes
Feb 5, 2003·Biology of the Cell·Véronique Cruciani, Svein Ole Mikalsen
May 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Doreen Siu Yi LeungBernhard Reuss
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Juan M GarréVerónica Abudara
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·N RouachC Giaume
Dec 18, 2004·Journal of Neuroscience Research·Joanna RozyczkaJürgen Engele
Dec 17, 2009·Brain Research Reviews·Vitali Matyash, Helmut Kettenmann
Oct 27, 2017·Macromolecular Bioscience·Gabriella C J BrownTim B F Woodfield
Jan 6, 2012·Molecular BioSystems·Kurt A SchalperJuan C Sáez
Jun 22, 2017·Neurochemical Research·Marijke De BockChristian Giaume
Oct 10, 2002·The European Journal of Neuroscience·Karen SchlüterJürgen Engele
Jun 9, 2016·Development, Growth & Differentiation·Camilla BosoneDiego Echevarria

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