Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo

Molecular and Cellular Neurosciences
D R GoddardA M Butt

Abstract

Fibroblast growth factor-2 (FGF-2) controls in part the timely differentiation of oligodendrocytes into the myelin-producing cells of the CNS. However, although differentiated oligodendrocytes express FGF receptors (R), the effect of FGF-2 on myelin-producing oligodendrocytes in vivo was unknown. In the present study, we show that delivery of FGF-2 into the cerebrospinal fluid of anaesthetized rat pups, aged postnatal day (P) 6 to 9, induced a severe loss of myelin in the caudal anterior medullary velum (AMV). Furthermore, we show that the caudal AMV was myelinated at the time of treatment, so the effects of FGF-2 represent a loss of myelin and not delayed differentiation. This was confirmed by injection of platelet-derived growth factor-AA (PDGF-AA), a factor known to affect the differentiation of PDGF-alphaR expressing oligodendrocyte progenitors, but which did not induce myelin loss in the caudal AMV and did not affect differentiated oligodendrocytes, which do not express PDGF-alphaR. Compared to controls treated with saline or PDGF-AA, FGF-2 induced an accumulation of PLP protein and MBP mRNA within the somata of myelin-producing oligodendrocytes. The results indicate that FGF receptor signalling disrupts myelin production ...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O BöglerM Noble
Apr 1, 1989·Journal of Neuroscience Research·R Wilson, P J Brophy
Apr 1, 1986·Journal of Neurocytology·C S Raine, M Dolich
Dec 1, 1993·Trends in Neurosciences·P J BrophyD R Colman
Feb 1, 1995·Current Opinion in Cell Biology·E Mandelkow, E M Mandelkow
Jan 1, 1994·Progress in Growth Factor Research·A LoganM Berry
Aug 1, 1996·Experimental Neurology·J F Reilly, V G Kumari
Dec 1, 1995·Journal of Neurocytology·M BerryA M Butt
Aug 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J GreenP Doherty
Apr 1, 1996·Molecular and Cellular Neurosciences·R BansalS E Pfeiffer
Jan 1, 1996·Developmental Neuroscience·R J Hardy, V L Friedrich
Jan 1, 1996·Molecular and Cellular Neurosciences·P Doherty, F S Walsh
Apr 1, 1996·Journal of Neuroscience Research·D A Muir, D A Compston
Aug 1, 1996·Molecular and Cellular Neurosciences·P Doherty, F S Walsh
Mar 15, 1997·Journal of Neuroscience Research·E CouveM Roncagliolo
May 1, 1997·Journal of Neurocytology·K F LunnI D Duncan
Feb 12, 1998·Journal of Neuroscience Research·R Bansal, S E Pfeiffer
Jan 1, 1997·Cell Motility and the Cytoskeleton·J H CarsonE Barbarese
Feb 5, 2000·Journal of Neuroscience Research·C Richter-Landsberg
Nov 21, 2000·Molecular and Cellular Neurosciences·G L Hinks, R J Franklin

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Citations

Jul 10, 2007·Nature Neuroscience·Adan AguirreVittorio Gallo
Feb 9, 2002·Journal of Anatomy·Diane R GoddardArthur M Butt
Jan 9, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chitose SugiuraKousaku Ohno
Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin E Deverman, Paul H Patterson
Apr 23, 2004·Expert Opinion on Investigational Drugs·Martin Stangel
Apr 29, 2009·The Journal of Comparative Neurology·Terry C BurnsWalter C Low
Jul 11, 2008·The Journal of Comparative Neurology·Richa B Tripathi, Dana M McTigue
Sep 22, 2010·Journal of Neuroscience Research·Craig S MooreStephen J Crocker
Mar 27, 2016·Experimental Neurology·Natalie A Wheeler, Babette Fuss
Feb 9, 2005·Experimental Neurology·Arthur M Butt, Jennifer Dinsdale
Aug 1, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mascha S RecksStefanie Kuerten
Jan 2, 2015·Cellular and Molecular Life Sciences : CMLS·Benjamin FörthmannPeter Claus
Mar 25, 2014·Frontiers in Cellular Neuroscience·Viktoria GudiMartin Stangel
Jun 4, 2015·PloS One·Marta Tejera-AlhambraSilvia Sánchez-Ramón
Mar 23, 2004·Molecular and Cellular Neurosciences·Julia JungnickelClaudia Grothe
Feb 11, 2004·Experimental Neurology·Laurent MagyAnne Baron-Van Evercooren
Sep 5, 2002·Nature Reviews. Neuroscience·Robin J M Franklin
May 22, 2013·Cellular and Molecular Life Sciences : CMLS·Fernando de CastroMaria Cristina Ortega
Nov 6, 2014·Biomolecular Concepts·Tatsuhide Tanaka, Shigetaka Yoshida
Mar 20, 2003·Journal of Neuroscience Research·Patrizia Casaccia-Bonnefil, Aixiao Liu
Mar 10, 2017·Annals of Clinical and Translational Neurology·Mathieu MarellaPaula J Lapinskas
Sep 30, 2020·Mechanisms of Ageing and Development·Paraskevi N KoutsoudakiVassilis G Gorgoulis
Jun 10, 2021·Journal of Psychiatric Research·Sara PolettiFrancesco Benedetti
May 20, 2004·Experimental Cell Research·Pamela E Knapp, Mary H Adams
Jun 30, 2021·Molecular and Cellular Neurosciences·Viridiana Vargas-CastroBertha Alicia Leon-Chavez

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