Fibroblast growth factor-2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Guomin OuGloria Gronowicz

Abstract

The potential of fibroblast growth factor-2 (FGF-2) to stimulate osteoprogenitors in aging bone was investigated. Previous work showed a decrease in bone formation in cell cultures derived from bone of elderly female patients, but not in cells from age-matched male or younger female patients, with transforming growth factor β increasing bone formation but not increasing osteoprogenitors. In the present study, FGF-2 was shown to significantly stimulate, in a dose-dependent manner, proliferation of mesenchyme-derived progenitor cells from bones of young and old mouse and humans. In proliferation assays, human cells were more responsive to lower concentrations (0.0016 ng/mL) of FGF-2 than mouse cells, but proliferation was less in cells from older bone. Immunofluorescence microscopy revealed that FGF-2 increased and prevented the decline in cells expressing activated leukocyte cell adhesion molecule, a novel marker for early lineage osteoblasts, but not α-smooth muscle actin. FGF-2 may have therapeutic potential for stimulating osteoblast progenitors in aging.

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Citations

Mar 28, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Liisa T KuhnGloria Gronowicz
Sep 7, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wacharaporn TiyasatkulkovitSuchinda Malaivijitnond
Dec 22, 2016·Journal of Biomedical Materials Research. Part a·E E JacobsL T Kuhn
Jul 25, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yaqian ChenYi Man
Oct 20, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Karen B SagomonyantsGloria Gronowicz
Oct 5, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Gloria GronowiczLiisa T Kuhn

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