Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity.

Endocrine Research
Elizabeth F SuttonLeanne M Redman

Abstract

The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood. Serum FGF21 was measured during the first and third trimesters. Placentas were collected at delivery. Maternal FGF21 concentrations were positively correlated with body mass index and adiposity, but not lean mass or glucose homeostasis. FGF21 concentrations significantly increased from the first to third trimester of pregnancy (0.105 vs. 0.256 ng/mL, p < 0.0001). Changes in FGF21 concentrations across pregnancy were not associated with changes in body weight or composition but inversely with the change in fasting glucose. FGF21 mRNA levels in placenta were very low and do not likely contribute to FGF21 in the maternal circulation. FGF21 increases throughout pregnancy in our healthy cohort with overweight and obesity, independent of the placenta, and does not appear to be sensing the change...Continue Reading

References

Jul 1, 1988·The American Journal of Clinical Nutrition·J M van RaaijJ G Hautvast
Jan 5, 2002·Obstetrics and Gynecology·UNKNOWN ACOG Committee Obstetric Practice
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Oct 28, 2006·Endocrinology·Alexei KharitonenkovGarret J Etgen
Oct 11, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·W-W ChenG Boden
Aug 9, 2008·Endocrinology·Tamer CoskunAlexei Kharitonenkov
Aug 30, 2008·Diabetes Research and Clinical Practice·Ling LiWenwen Chen
Aug 25, 2009·Metabolism: Clinical and Experimental·Sebastian SteinMathias Fasshauer
May 11, 2010·Gastroenterology·Jody DushayEleftheria Maratos-Flier
Jun 15, 2013·Endocrinology·João Paulo G CamporezGerald I Shulman
Sep 10, 2013·Cell Metabolism·Gregory GaichDavid E Moller
Jan 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Marloes Dekker NitertLeonie K Callaway
May 13, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Gallego-EscuredoF Villarroya
Jun 6, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yingjun CuiYves R Boisclair
Jan 22, 2015·Acta Diabetologica·Ana MegiaJoan Vendrell
Apr 19, 2015·Reproductive Biology and Endocrinology : RB&E·Marloes Dekker NitertHelen L Barrett
Feb 19, 2016·The American Journal of Clinical Nutrition·Nicole E MarshallJonathan Q Purnell
Feb 9, 2017·Obstetrics and Gynecology·Elizabeth F SuttonLeanne M Redman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.