Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice

Endocrinology
Karlton R LarsonKaren K Ryan

Abstract

Whereas carbohydrates and lipids are stored as glycogen and fat, there is no analogous inert storage form of protein. Therefore, continuous adjustments in feeding behavior are needed to match amino acid supply to ongoing physiologic need. Neuroendocrine mechanisms facilitating this behavioral control of protein and amino acid homeostasis remain unclear. The hepatokine fibroblast growth factor-21 (FGF21) is well positioned for such a role, as it is robustly secreted in response to protein and/or amino acid deficit. In this study, we tested the hypothesis that FGF21 feeds back at its receptors in the nervous system to shift macronutrient selection toward protein. In a series of behavioral tests, we isolated the effect of FGF21 to influence consumption of protein, fat, and carbohydrate in male mice. First, we used a three-choice pure macronutrient-diet paradigm. In response to FGF21, mice increased consumption of protein while reducing carbohydrate intake, with no effect on fat intake. Next, to determine whether protein or carbohydrate was the primary-regulated nutrient, we used a sequence of two-choice experiments to isolate the effect of FGF21 on preference for each macronutrient. Sweetness was well controlled by holding sucrose...Continue Reading

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Citations

Mar 29, 2019·The Journal of Physiology·Stephanie von Holstein-Rathlou, Matthew P Gillum
Jul 25, 2019·Obesity·David Raubenheimer, Stephen J Simpson
Feb 13, 2020·Endocrinology·Cristal M HillChristopher D Morrison
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Jul 8, 2021·American Journal of Physiology. Endocrinology and Metabolism·Yasaman BadakhshiTianru Jin
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Nov 5, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kota YanoYoshito Itoh
Jan 21, 2022·Molecular Metabolism·Nnamdi G NelsonAllison W Xu

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