Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet

The Journal of Nutrition
Lei HaoA Catharine Ross

Abstract

Fibroblast growth factor 21 (FGF21) is a regulator of carbohydrate and lipid metabolism; however, the regulation of Fgf21 gene expression by diet remains incompletely understood. We investigated the effect of a high-carbohydrate (HC) liquid diet, with and without supplementation with a lipid emulsion (LE), and of a high-fat diet (HFD) compared with a low-fat diet (LFD) on the regulation of Fgf21 gene expression in the liver of intact mice. C57BL/6 male mice were fed standard feed pellets (SFPs), a purified HC liquid diet (adequate in calories and protein), or an HC liquid diet containing an LE at either 4% or 13.5% of energy for 5 wk (Expt. 1) or 1 wk (Expt. 2). In Expt. 3, mice were fed a purified LFD (∼10% fat) or HFD (∼60% fat) or were fed an HFD and given access to a running wheel for voluntary exercise for 16 wk. Fgf21 mRNA in liver and FGF21 protein in plasma were increased by 3.5- to 7-fold in HC mice compared with SFP mice (P < 0.001), whereas the LE dose-dependently attenuated the induction of Fgf21 expression (P < 0.05). After 16 wk, hepatic Fgf21 mRNA did not differ between LFD and HFD mice but was dramatically reduced in the HFD+exercise group to <20% of the level in the HFD group (P < 0.0001). In mice, hepatic Fgf2...Continue Reading

References

Jun 20, 2000·Biochimica Et Biophysica Acta·T NishimuraN Itoh
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Aug 4, 2006·The Journal of Biological Chemistry·Lin MaHoward C Towle
Jul 3, 2007·Biochemical and Biophysical Research Communications·Thomas LundåsenMats Rudling
Jan 25, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alexei Kharitonenkov, Armen B Shanafelt
Aug 9, 2008·Endocrinology·Tamer CoskunAlexei Kharitonenkov
Oct 13, 2009·Endocrinology·Michael K BadmanEleftheria Maratos-Flier
Jul 30, 2010·Molecular Endocrinology·Klementina Fon TacerSteven A Kliewer
Feb 4, 2012·Genes & Development·Matthew J PotthoffDavid J Mangelsdorf
Jun 16, 2012·PloS One·Daniel Cuevas-RamosCarlos A Aguilar-Salinas
Aug 16, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Justin A FletcherR Scott Rector
Apr 9, 2014·Trends in Endocrinology and Metabolism : TEM·Ruth E Gimeno, David E Moller
Aug 19, 2014·The Journal of Clinical Investigation·Thomas LaegerChristopher D Morrison

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Citations

Sep 2, 2016·Hormone Molecular Biology and Clinical Investigation·Albert Pérez-MartíJoana Relat
Jun 26, 2020·Journal of Cellular Physiology·Chang GuoGuoyue Yuan
Jun 11, 2016·Hormone Molecular Biology and Clinical Investigation·Anjeza Erickson, Régis Moreau
May 20, 2020·Antioxidants·Nady BraidySam van Eeden
Sep 25, 2019·International Journal of Molecular Sciences·Úrsula Martínez-GarzaJoana Relat

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