Abstract
FGF21 is a hormonal factor with important functions in the control of metabolism. FGF21 is found in rodent and human milk. Radiolabeled FGF21 administered to lactating dams accumulates in milk and is transferred to neonatal gut. The small intestine of neonatal (but not adult) mice highly expresses β-Klotho in the luminal area. FGF21-KO pups fed by FGF21-KO dams showed decreased expression and circulating levels of incretins (GIP and GLP-1), reduced gene expression of intestinal lactase and maltase-glucoamylase, and low levels of galactose in plasma, all associated with a mild decrease in body weight. When FGF21-KO pups were nursed by wild-type dams (expressing FGF21 in milk), intestinal peptides and digestive enzymes were up-regulated, lactase enzymatic activity was induced, and galactose levels and body weight were normalized. Neonatal intestine explants were sensitive to FGF21, as evidenced by enhanced ERK1/2 phosphorylation. Oral infusion of FGF21 into neonatal pups induced expression of intestinal hormone factors and digestive enzymes, lactase activity and lactose absorption. These findings reveal a novel role of FGF21 as a hormonal factor contributing to neonatal intestinal function via its presence in maternal milk. Appro...Continue Reading
References
Dec 1, 1991·The Journal of Endocrinology·C G ProsserR B Heap
Dec 22, 1990·Lancet·A Lucas, T J Cole
Jun 1, 1986·The Journal of Endocrinology·K D BrownR B Heap
Aug 1, 1969·Gut·P R SalmonC F McCarthy
Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·A Dahlqvist
Mar 1, 1995·The Biochemical Journal·G AsinsF G Hegardt
Dec 1, 1993·Endocrine Reviews·C E GrosvenorC R Baumrucker
Apr 1, 1996·European Journal of Biochemistry·D SerraF G Hegardt
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·S M Smith-KirwinV L Funanage
Jun 19, 2003·The American Journal of Clinical Nutrition·Bo Lönnerdal
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Oct 24, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Francesco Savino, Stefania A Liguori
Mar 12, 2008·Clinical Reviews in Allergy & Immunology·Carol L WagnerDonna Johnson
Oct 14, 2008·Genes & Nutrition·C PicóA Palou
Feb 13, 2010·The Journal of Pediatrics·Bohuslav Dvorak
Feb 13, 2010·The Journal of Pediatrics·David S NewburgArdythe L Morrow
Mar 4, 2010·Cell Metabolism·Elayne HondaresFrancesc Villarroya
Jul 30, 2010·Molecular Endocrinology·Klementina Fon TacerSteven A Kliewer
Jan 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Yoshihisa OhtaniKazuo Katoh
Feb 15, 2011·The Journal of Biological Chemistry·Elayne HondaresFrancesc Villarroya
Oct 13, 2011·Endocrinology·Katie M SchoenbergYves R Boisclair
Feb 7, 2012·Cell·Paul A DutchakSteven A Kliewer
May 17, 2012·Current Diabetes Reviews·A C Adams, A Kharitonenkov
Aug 7, 2012·Stem Cells·Foteini HassiotouPeter E Hartmann
Jun 19, 2013·Nature Communications·A PlanavilaF Villarroya
Feb 14, 2014·Acta Paediatrica·Brigitte BrandsUNKNOWN EarlyNutrition Project
Citations
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ericka A de Los RíosYazmín Macotela
Feb 16, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aleix Gavaldà-NavarroIgnacio R Ipharraguerre
Jul 9, 2017·Molecular Nutrition & Food Research·Yalin LiaoBo Lönnerdal
Jun 27, 2018·American Journal of Physiology. Endocrinology and Metabolism·Emmanuel SommNelly Pitteloud
Nov 18, 2016·Nature Communications·Tania Quesada-LópezFrancesc Villarroya
Aug 14, 2019·PloS One·Cesar G TorizMaria Eugenia Mendoza-Garrido
Dec 27, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Geula Hanin, Anne C Ferguson-Smith
Nov 24, 2016·Journal of Internal Medicine·A Kharitonenkov, R DiMarchi
Jul 3, 2018·Frontiers in Physiology·Lorenz BirnbacherTobias Fromme
Jul 31, 2019·American Journal of Physiology. Endocrinology and Metabolism·Tania Quesada-LópezFrancesc Villarroya
Aug 15, 2020·Frontiers in Microbiology·Christian Albert DevauxDidier Raoult
Jul 1, 2020·Nutrients·Paulina Torres-CastroÀngels Franch
Aug 29, 2018·Nutrients·Paulina Torres-CastroÀngels Franch
Feb 18, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Lucie MarousezDelphine Eberlé
May 1, 2021·Nutrients·Blanca Grases-PintóÀngels Franch