Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus.

Frontiers in Molecular Neuroscience
Rishabh SinghMichael A Fox

Abstract

At least three forms of signaling between pre- and postsynaptic partners are necessary during synapse formation. First, "targeting" signals instruct presynaptic axons to recognize and adhere to the correct portion of a postsynaptic target cell. Second, trans-synaptic "organizing" signals induce differentiation in their synaptic partner so that each side of the synapse is specialized for synaptic transmission. Finally, in many regions of the nervous system an excess of synapses are initially formed, therefore "refinement" signals must either stabilize or destabilize the synapse to reinforce or eliminate connections, respectively. Because of both their importance in processing visual information and their accessibility, retinogeniculate synapses have served as a model for studying synaptic development. Molecular signals that drive retinogeniculate "targeting" and "refinement" have been identified, however, little is known about what "organizing" cues are necessary for the differentiation of retinal axons into presynaptic terminals. To identify such "organizing" cues, we used microarray analysis to assess whether any target-derived "synaptic organizers" were enriched in the mouse dorsal lateral geniculate nucleus (dLGN) during ret...Continue Reading

Citations

Apr 3, 2016·Behavioural Brain Research·Aislinn J WilliamsHisashi Umemori
Mar 17, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·David M Ornitz, Nobuyuki Itoh
Nov 5, 2013·Cell Reports·Justin M BrooksMichael A Fox
Jun 18, 2016·Journal of Neurochemistry·Maria J Pinto, Ramiro D Almeida
Feb 24, 2018·Frontiers in Neural Circuits·Gabriela L CarrilloMichael A Fox
Oct 17, 2018·Journal of Neurochemistry·Ubadah SabbaghMichael A Fox
Oct 3, 2017·Visual Neuroscience·Aboozar MonavarfeshaniMichael A Fox
Feb 26, 2019·Frontiers in Pharmacology·Zheng DengMi-Mi Tang

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Methods Mentioned

BETA
Feature Extraction
PCR
protein assay

Software Mentioned

Adobe Photoshop
ImageJ
GenUs
Agilent Feature Extraction
dLGN
GeneSpring GX

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