Fibroblast growth factor 23 concentrations in healthy term infants during the early postpartum period

Bone
Masanori TakaiwaTsuneo Morishima

Abstract

Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the significance of FGF23 during the early postpartum period, we examined the circulating FGF23 levels using an intact FGF23 ELISA and a C-terminal FGF23 ELISA either in 22 umbilical cord blood samples (the cord blood) or in 22 term infants at 5days of life (the 5-day-old infant). We also compared these ranges with those of 11 healthy adults. Data were expressed as mean+/-SD, and analyzed by two-way ANOVA, followed by the Tukey's test. C-terminal FGF23 in the cord blood, the 5-day-old infants and the healthy adults were 73.3+/-22.4, 81.0+/-28.2 and 39.0+/-7.8 RU/ml, respectively. Intact FGF23 in the cord blood, the 5-day-old infants and the healthy adults were 3.9+/-1.6, 21.8+/-17.6, and 27.6+/-7.3 pg/ml, respectively. Immunoprecipitation assays using anti-FGF23 antibodies demonstrated that the intact 32 kDa FGF23 was low and the fragmented FGF23 of 18kDa was abundant in the cord blood compared with those in the healthy adults...Continue Reading

References

May 1, 1988·American Journal of Diseases of Children·J L LougheadR C Tsang
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Dec 12, 2001·Kidney International·K E WhiteM J Econs
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Yuji YamazakiSeiji Fukumoto
Apr 25, 2003·The New England Journal of Medicine·Kenneth B JonssonHarald Jüppner
Jul 23, 2004·Bone·Anna Benet-PagèsTim M Strom
Feb 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Tobias LarssonKenneth E White
Mar 8, 2005·Gene Expression Patterns : GEP·Sarah CormierCaroline Silve
Aug 4, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takeyoshi Yamashita
Dec 31, 2005·European Journal of Endocrinology·Keisuke KobayashiYoshiki Nishizawa
Jan 27, 2006·The Journal of Biological Chemistry·Hiroshi KurosuMakoto Kuro-o
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shiguang LiuL Darryl Quarles
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sherri -Ann M BurnettJoel S Finkelstein
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Shoji IchikawaMichael J Econs
Mar 14, 2007·Bone·Yuji YoshikoNorihiko Maeda
Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Azarmindokht KhosraviMichael T Collins
Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Emily G FarrowKenneth E White
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sherri-Ann M Burnett-BowieBenjamin Z Leder
Jun 12, 2009·American Journal of Physiology. Renal Physiology·Jyothsna GattineniMichel Baum

❮ Previous
Next ❯

Citations

Sep 10, 2011·Current Osteoporosis Reports·Christopher S Kovacs
Apr 19, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J BacchettaI B Salusky
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Jan 17, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nisan BhattacharyyaMichael T Collins
Jan 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yasuhisa OhataToshimi Michigami
May 15, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Tarah FataniCelia Rodd
Jan 29, 2019·International Urology and Nephrology·Zhongyan LiuJing Zheng
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Elisa Holmlund-SuilaOuti Mäkitie
Jan 15, 2017·Nephrology·Ashok Kumar YadavVivekanand Jha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Charlene S SimmondsChristopher S Kovacs
The Journal of Clinical Investigation
Christopher S KovacsH M Kronenberg
The Journal of Clinical Endocrinology and Metabolism
H T ViljakainenC Lamberg-Allardt
© 2021 Meta ULC. All rights reserved