Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles

Journal of Molecular Cell Biology
Hui LiuXu Zhang

Abstract

Fibroblast growth factor (FGF) 7, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. However, its functions in the nervous system are largely unknown. The present study showed that FGF7 was a neuromodulator localized in the large dense-core vesicles (LDCVs) in nociceptive neurons. FGF7 was mainly expressed in small-diameter neurons of the dorsal root ganglion and could be transported to the dorsal spinal cord. Interestingly, FGF7 was mostly stored in LDCVs that did not contain neuropeptide substance P. Electrophysiological recordings in the spinal cord slice showed that buffer-applied FGF7 increased the amplitude of excitatory post-synaptic current evoked by stimulating the sensory afferent fibers. Behavior tests showed that intrathecally applied FGF7 potentiated the formalin-induced acute nociceptive response. Moreover, both acute and inflammatory nociceptive responses were significantly reduced in Fgf7-deficient mice. These results suggest that FGF7 exerts an excitatory modulation of nociceptive afferent transmission.

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Citations

Sep 1, 2015·Neuroscience Letters·Fausto Pierdoná GuzenJeferson Sousa Cavalcante
Nov 27, 2016·The Laryngoscope·Ceren GünelNuket Eliyatkin
Jul 31, 2018·Brain : a Journal of Neurology·Joanna SzczurkowskaLaura Cancedda
Apr 24, 2020·Current Drug Targets·Fatemeh Forouzanfar, Hamid R Sadeghnia
Apr 17, 2021·Molecular Neurobiology·Lars Klimaschewski, Peter Claus
May 31, 2021·Annals of Clinical and Translational Neurology·Phanidhar KukutlaGary J Brenner

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