Fibroblast growth factor decreases locomotor activity in rats

Neuroscience
C GuazaG Giménez-Gallego

Abstract

The spontaneous locomotor behavior of rats receiving subcutaneous administration of either acidic or basic fibroblast growth factors was recorded in an activity cage. We report that doses between 1 and 100 micrograms/kg significantly decreased the horizontal and vertical activity, as well as the exploratory and stereotypy behavior of the rats. These effects of fibroblast growth factors seem to be specific since (i) they were cancelled by protein hydrolysis and anti-fibroblast growth factor antibodies, (ii) they were unrelated to their hypotensive activity and (iii) they were not attributable to their high structural similarity with the cytokine interleukin-1. Thus fibroblast growth factors did not show any thermogenic activity, did not affect the hypothalamic output of corticotropin-releasing factor and did not change the plasma levels of corticosterone. Pretreatment of the rats with a specific inhibitor of brain nitric oxide synthase prevented the effects of fibroblast growth factors, suggesting the involvement of nitric oxide in these behavioral modifications. Our results contribute to the accumulating evidence describing non-mitogenic activities of fibroblast growth factors.

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Sep 1, 1992·Brain Research Bulletin·Z De Saint Hilaire, S Nicolaïdis
Dec 28, 1992·Science·D E Koshland
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
May 15, 1991·Biochemical and Biophysical Research Communications·M A DwyerS H Snyder
Apr 1, 1991·Trends in Pharmacological Sciences·S H Snyder, D S Bredt
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A J BeanT Hökfelt
Nov 22, 1991·Science·P CuevasG Giménez-Gallego
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K A ThomasS Fitzpatrick
Dec 1, 1989·Brain Research Bulletin·W A BanksD A Durham
Jan 1, 1988·Physiology & Behavior·I G OtternessG O Daumy
Jul 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·I Torres-AlemanA V Schally
Aug 1, 1994·Neurological Research·G Giménez-Gallego, P Cuevas
Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M A MenaJ Garcia de Yebenes
Feb 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M PrestaF Gremo
Dec 1, 1994·Journal of Neuroimmunology·E G GutierrezA J Kastin
Feb 1, 1994·Journal of Neurochemistry·R Guevara-GuzmanK M Kendrick
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
Mar 3, 1994·Nature·M FeelischS Moncada
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F PodusloC T Berg
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V K VijayanL F Eng
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NozakiM F Beal
Feb 16, 1993·European Journal of Pharmacology·A CalignanoL Sorrentino

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Citations

Apr 5, 1996·Neuroscience Letters·P CuevasG Giménez-Gallego
Apr 3, 2001·European Journal of Pharmacology·M HottaT Shibasaki
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A W Thorburn, J Proietto

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