Fibroblast growth factor-induced motor end plate regeneration in atrophic muscle

Archives of Otolaryngology--head & Neck Surgery
M A WalterJ A Thompson

Abstract

To determine whether fibroblast growth factor 1 implanted with viable nerve into atrophic muscle will stimulate formation of functional, acetylcholine producing motor end plates. Twelve male Lewis rats underwent predenervation of the hamstring muscle 8 weeks before implantation of the nerve at a site distant from the original motor end plate. Six animals underwent implantation of the tagged nerve ending into atrophic muscle with 50 microgram of fibroblast growth factor 1 in a fibrin adhesive carrier (group 1). Three animals underwent implantation with nerve, fibrin adhesive, and no fibroblast growth factor 1 (group 2); and three animals underwent implantation with fibroblast growth factor 1 and fibrin adhesive with no nerve (group 3). Animals were killed 9 weeks after implantation and nerve and muscle specimens were harvested. Histoenzymologic methods for acetylcholinesterase and silver impregnation of nerve fibers were performed 9 weeks after fibroblast growth factor 1-fibrin adhesive implantation. Variables included the number of motor end plates per highpower field and motor end plate length. Robust axonal sprouting and formation of multiple motor end plates were found arborized in serial fashion equidistant around the impla...Continue Reading

Citations

Jan 15, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaolin ZhangStanislaw Sobotka
Sep 18, 2004·Journal of Biomedical Materials Research. Part a·S S KelpkeJ A Thompson
Aug 24, 1999·Journal of Neurobiology·I Barakat-Walter
Jul 17, 2021·Frontiers in Pharmacology·Sven SeiwerthPredrag Sikiric
Apr 25, 2006·Archives of Biochemistry and Biophysics·Pei ZhangJohn A Thompson

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