Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer

Cancer Science
Mai TomiguchiHirotaka Iwase

Abstract

Recently, research into the development of new targeted therapies has focused on specific genetic alterations to create advanced, more personalized treatment. One of the target genes, fibroblast growth factor receptor-1 (FGFR1), has been reported to be amplified in estrogen receptor (ER)-positive subtype breast cancer, and is considered one possible mechanism of endocrine resistance through cross-talk between ER and growth factor receptor signaling. We performed a comprehensive analysis of FGFR1 at the levels of gene copy number, transcript and protein expression, and examined the relationships between FGFR1 status and clinicopathological parameters, including prognosis in 307 ER-positive/HER2-negative primary breast cancer patients treated with standard care at our institute. Most notably, a high level of FGFR1 protein expression was observed in 85 patients (27.7%), and was positively associated with invasive tumor size (P = 0.039). Furthermore, univariate analysis revealed that high FGFR1 protein expression was significantly correlated with poor relapse-free survival rate (P = 0.0019, HR: 2.63, 95% confidence interval: 1.17-5.98), and showed a tendency towards an increase in recurrent events if the observation period extended...Continue Reading

References

Jul 9, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aron GoldhirschHans-Jörg Senn
Sep 4, 2003·Genome Biology·Dov GreenbaumMark Gerstein
Sep 9, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jorge Sergio Reis-FilhoAlan Ashworth
Aug 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN 10th St. Gallen conference
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabrice AndreLajos Pusztai
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Dec 17, 2009·Clinical Genetics·M FanciulliT J Aitman
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cathy B MoelansPaul J van Diest
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricardo H AlvarezGabriel N Hortobagyi
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jul 26, 2011·The Breast : Official Journal of the European Society of Mastology·Antonis ValachisVassilios Georgoulias
Dec 6, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mutsuko IbusukiHirotaka Iwase
Jun 23, 2012·Nature·Philip J StephensMichael R Stratton
Aug 7, 2012·Breast Cancer Research : BCR·Min JangSo Park
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
May 10, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabrice AndréJosé Baselga
Sep 14, 2013·Journal of the National Cancer Institute·Ivana SestakJack Cuzick
Oct 26, 2013·British Journal of Cancer·P DubskyUNKNOWN Austrian Breast and Colorectal Cancer Study Group (ABCSG)
Jul 22, 2014·Nature·Bing ZhangUNKNOWN NCI CPTAC
Feb 11, 2015·International Journal of Clinical Oncology·Hirotaka Iwase
Feb 14, 2015·Breast Cancer Research and Treatment·Fabrice André, Javier Cortés
Apr 15, 2015·Breast Cancer Research and Treatment·Chee Leong ChengPuay Hoon Tan
Jun 11, 2015·BMC Medicine·Mutsuko Yamamoto-IbusukiFabrice André

❮ Previous
Next ❯

Citations

Mar 24, 2016·Asia-Pacific Journal of Clinical Oncology·Andrew RedfernRichard Bell
Oct 15, 2013·PloS One·Chandrani MukhopadhyayMayumi Naramura
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jia LiuZhong-Hou Han
Nov 23, 2017·Endocrine-related Cancer·Philipp Y MaximovV Craig Jordan
Aug 28, 2020·Breast Cancer Research and Treatment·Ramona ErberPeter A Fasching
Jun 29, 2018·International Journal of Molecular Sciences·Qi HuiXiaojie Wang
Jun 11, 2019·Frontiers in Endocrinology·Aradhana RaniJohn Murphy
Sep 4, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S N AleksakhinaA G Iyevleva
Oct 22, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena Guerini-RoccoMarco Colleoni
Nov 18, 2020·Expert Review of Anticancer Therapy·Jasmine SukumarNicole Williams
Jul 1, 2020·Recent Patents on Anti-cancer Drug Discovery·Xiangming Xu, Lei Yao

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
Genotyping
Assay
reverse transcription PCR
transgenic

Software Mentioned

JMP
MARKer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.