Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

Current Opinion in Gastroenterology
Mitesh J BoradLewis R Roberts

Abstract

This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 in CCA and future directions for understanding and targeting the FGFR2 pathway in this disease, will be discussed. Understanding the role of the FGFR2 pathway as a disease pathogenetic mechanism and the ability to develop targeted therapies and diagnostics surrounding this concept are critical elements toward developing novel targeted approaches in CCA.

References

Jan 23, 2010·Nature Reviews. Cancer·Nicholas Turner, Richard Grose
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Jul 31, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei-meng ZhaoK Jin Kim
May 9, 2012·Nature Genetics·Choon Kiat OngBin Tean Teh
Apr 6, 2013·Cancer Discovery·Yi-Mi WuArul M Chinnaiyan
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuhito AraiTatsuhiro Shibata
Mar 4, 2014·Lancet·Nataliya Razumilava, Gregory J Gores
May 3, 2014·Molecular Cancer Research : MCR·Jaime AcquavivaDavid A Proia
May 20, 2014·Human Pathology·Rondell P GrahamBenjamin R Kipp
Nov 11, 2014·Nature Medicine·Zongli ZhengLong Phi Le

❮ Previous
Next ❯

Citations

Sep 15, 2016·PloS One·Terence G HallGiovanni Abbadessa
Dec 9, 2016·Gut and Liver·Boris Blechacz
Feb 7, 2017·Expert Review of Gastroenterology & Hepatology·Douglas V N P OliveiraJesper B Andersen
Aug 21, 2018·Expert Opinion on Investigational Drugs·Amit MahipalRichard Kim
Nov 14, 2018·British Journal of Cancer·Vincenzo MazzaferroWalid L Shaib
Apr 8, 2020·International Journal of Molecular Sciences·Andreas ReicherLawrence N Kwong
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fabiana CrispoMatteo Landriscina
Jan 15, 2021·World Journal of Hepatology·Keun Soo Ahn, Koo Jeong Kang
Feb 24, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Tianyu WuYu Wang
Jan 15, 2021·Genome Research·Sebastian UhrigBenedikt Brors
May 2, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T S Bekaii-SaabN Normanno
Oct 16, 2021·Frontiers in Oncology·Zhonghua TaoXichun Hu
Oct 27, 2021·Expert Opinion on Investigational Drugs·Stephan BraunMarc Engelhardt
Oct 12, 2019·Gastrointestinal Tumors·Shunichi TsugeStephen J Meltzer

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
exome sequencing
surgical resections

Clinical Trials Mentioned

NCT02150967
NCT02265341

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Nederlands tijdschrift voor geneeskunde
N A van der GaagD J Gouma
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Yanru HuangQian Pan
© 2021 Meta ULC. All rights reserved