Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer

International Journal of Biological Sciences
Haipeng Lei, Chu-Xia Deng

Abstract

Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types of cancers, including breast cancer, lung cancer, gastric cancer, uterine cancer and ovarian cancer, yet the casual relationship between these mutations and tumorigenesis is unclear. Here we will discuss possible interactions between FGFR2 signaling and several major pathways through which the aberrantly activated FGFR2 signaling may result in breast cancer development. We will also discuss some recent developments in the discovery and application of therapies and strategies for breast cancers by inhibiting FGFR2 activities.

Citations

Feb 20, 2019·Genes·Valentina A ZavalaLaura Fejerman
Apr 15, 2020·PLoS Computational Biology·Olga A VsevolozhskayaDmitri V Zaykin
Jul 19, 2019·Experimental and Therapeutic Medicine·Yu SunKun Han
Jul 3, 2021·Breast Cancer Research and Treatment·Naoko Hashimoto TakigamiHironobu Sasano
Oct 10, 2021·The Lancet. Gastroenterology & Hepatology·Audrey E KamRachna T Shroff

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Methods Mentioned

BETA
nuclear translocation
xenograft

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