Fibroblast Growth Factor Receptor Function Is Required for the Orderly Projection of Ganglion Cell Axons in the Developing Mammalian Retina

Molecular and Cellular Neurosciences
P A BrittisP Doherty

Abstract

During the early stages of development various cell adhesion molecules (CAMs) and fibroblast growth factor receptors (FGFR) are expressed throughout the retinal neuroepithelium. The ability of retinal ganglion cells to project their axons to the optic fissure depends, in part, on cell-cell interactions mediated by cell adhesion molecules. In the present study we show that the ability of the firstborn rat retinal ganglion cells to extend axons in vitro can be stimulated by NCAM and L1, but not N-cadherin. Both CAM responses can be fully inhibited by antibodies that block neuronal fibroblast growth factor receptor function and by agents that block defined steps in the FGFR signal transduction cascade. When added to living E13.5 rat retinal whole-mount preparations the same agents induced errors in the orderly establishment of young axon patterns in the retinal periphery and caused axons in the retinal center to defasciculate. These results suggest that the activation of the fibroblast growth factor receptor signal cascade not only promotes survival and proliferation of various cell types but can also mediate intraretinal axon guidance.

Citations

Oct 20, 1999·The Journal of Cell Biology·M M LedigB K Mueller
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Kenwrick, P Doherty
Jan 1, 1997·Annual Review of Cell and Developmental Biology·F S Walsh, P Doherty
Mar 17, 2004·The Journal of Comparative Neurology·Kit-Ying ChungSun-On Chan
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melina ReisenbergPatrick Doherty
Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·X GuillonneauF Mascarelli
Jun 4, 2008·The Journal of Comparative Neurology·Juan SuárezFernando Rodríguez de Fonseca
Feb 13, 2003·The Journal of Cell Biology·Emma-Jane WilliamsPatrick Doherty
Nov 23, 2011·The European Journal of Neuroscience·Madeleine J OudinPatrick Doherty
Jul 5, 2001·The Journal of Comparative Neurology·K Y ChungS O Chan
Dec 26, 2015·Biology·Mirka HomrichSimone Diestel
Nov 21, 2014·Nature Reviews. Neuroscience·Mauro MaccarroneTibor Harkany
Dec 23, 2000·Molecular and Cellular Neurosciences·P Tejero-DíezF J Díez-Guerra
Nov 22, 2000·Molecular and Cellular Neurosciences·P DohertyE J Williams
Dec 1, 2001·Progress in Neurobiology·S D SkaperF S Walsh
Jun 26, 2001·Brain Research. Brain Research Reviews·S Thanos, J Mey
Aug 5, 2000·Progress in Retinal and Eye Research·H K Yip, K F So
Aug 22, 2007·Trends in Cell Biology·S McFarlane, C E Holt
Jun 1, 2000·Progress in Neurobiology·C A Stuermer, M Bastmeyer
Dec 11, 2003·Molecular and Cellular Neurosciences·Przemyslaw S SapiehaAdriana Di Polo
Jun 23, 2004·Molecular and Cellular Neurosciences·John J ForniGuy Tear
Jan 19, 2006·Current Opinion in Neurobiology·Esther T Stoeckli
Apr 2, 2008·Molecular and Cellular Neurosciences·Sheona WatsonAnthony Graham
Jun 20, 2008·Molecular and Cellular Neurosciences·Maria Beatriz GoncalvesPatrick Doherty

❮ Previous
Next ❯

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.