Fibroblast growth factor signaling in mammalian tooth development

Odontology
Chun-Ying LiOphir Klein

Abstract

In this review, we discuss the central role of fibroblast growth factor (FGF) signaling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogene...Continue Reading

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Citations

Dec 17, 2015·Genesis : the Journal of Genetics and Development·Matthew J AndersonMark Lewandoski
Jun 19, 2015·Evolution & Development·Vagan TapaltsyanOphir D Klein
Sep 26, 2015·Journal of Colloid and Interface Science·Carolina Torres-RodríguezMaría Vallet-Regí
Jan 9, 2015·Journal of Dental Research·T H KimE S Cho
Feb 7, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ji-Myung BaeAmjad Javed
Jun 1, 2017·Development·Marika Kapsimali
Nov 16, 2018·Clinical Dysmorphology·Muserref BasdemirciMahmut S Yildirim
Mar 16, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nasim RostampourJulia C Boughner
Jan 11, 2019·International Journal of Oncology·Yilong HaoQianming Chen
Oct 21, 2018·International Journal of Molecular Sciences·Anna Schliermann, Joachim Nickel
Oct 22, 2015·The Journal of Biological Chemistry·Tian MengYongbo Lu
Jan 26, 2020·Development·Tingsheng Yu, Ophir D Klein
May 2, 2018·Stem Cells International·Wen DuHaiyang Yu
Nov 19, 2020·Journal of Molecular Histology·Hao ZhangGuobin Yang
Aug 7, 2021·Frontiers in Pharmacology·Keyue LiuBo Gao
Aug 24, 2021·European Journal of Orthodontics·Tsun Man ChoiEdwin Mattheus Ongkosuwito
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Yam Prasad AryalJae-Young Kim

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