Fibroblast growth factors 1 and 2 and fibroblast growth factor receptor 1 are elevated in thyroid hyperplasia

The Journal of Clinical Endocrinology and Metabolism
S D ThompsonM C Eggo

Abstract

We have previously reported increased expression of fibroblast growth factor (FGF-1 and FGF-2) in benign and malignant human thyroid neoplasia. To determine the role of these factors in thyroid hyperplasia we have examined their expression in multinodular goiter and compared findings with those in normal thyroid tissue. Because the effects of FGF-1 and FGF-2 are predominantly mediated through the FGF receptor-1 (FGFR-1), its expression has also been examined. Immunocytochemistry was performed on sections from multinodular goiters (n = 18) and normal thyroid (n = 7). Cytoplasmic staining for FGF-1, FGF-2, and FGFR-1 was scored on a scale of 0 (no staining) to 3 (heavy staining) and expressed as a percentage of total cells stained. Confocal microscopy of immunofluorescent staining for FGF-1, FGF-2, and FGFR-1 in sections of multinodular goiter (n = 3) and normal thyroid (n = 3) provided quantitation of immunostaining. FGF-1 expression was significantly increased in multinodular goiter when compared with normal. A mean of 74% of follicular cells in multinodular goiter compared with 9% of follicular cells in normal thyroid expressed FGF-1 (P < 0.0001). When expression of FGF-2 was examined, 77% of the follicular cells in multinodul...Continue Reading

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Citations

Jul 30, 2010·Molecular Endocrinology·Klementina Fon TacerSteven A Kliewer
Jul 29, 2009·Journal of Endocrinological Investigation·M AlbaS M Corsello
Apr 28, 2006·Molecular Biology of the Cell·Chen WangNaihe Jing
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Meyer Knobel, Geraldo Medeiros-Neto
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Astrid KehlenCuong Hoang-Vu
Jun 21, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sofia Tseleni-BalafoutaEfstratios Patsouris
Mar 8, 2019·Endocrine Journal·Sadegh RajabiMehdi Hedayati
Oct 23, 2003·Endocrine Reviews·Helen E TurnerJohn A H Wass
Oct 5, 2010·Annals of the Royal College of Surgeons of England·John C Watkinson
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Vimal A PatelMargaret C Eggo
Jun 5, 2003·Clinical Endocrinology·Chris J McCabe, Anthony P Heaney
May 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Helen C CocksMargaret C Eggo
Feb 16, 2008·The American Journal of Pathology·Anne-Catherine GérardFabrice Soncin
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Allan J WilliamsGraham R Williams

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