PMID: 7543993May 26, 1995Paper

Fibroblast growth factors alter light responses and dark voltage in retinal rods of the frog (Rana temporaria)

Neuroscience Letters
K F SchmidtY Courtois

Abstract

Fibroblast growth factors (FGF-1 and FGF-2) were applied intracellularly via whole-cell patch-clamp electrodes while the membrane voltage was recorded simultaneously. During recording the exchange of substances by diffusion between cytosol and pipette medium affects the cell's function. Under control conditions, the loss of nucleotides is reflected by a slow hyperpolarization of the dark voltage and prolongated light responses. Addition of FGF-1 and FGF-2 to the pipette medium accelerated the time course of the hyperpolarization and intensified the prolongation of the light responses. The depolarization of photoreceptor cells after intracellular application of the nitric oxide (NO)-synthase cofactor nicotinamide adenine dinucleotide phosphate (NADPH) and the stabilization of light response recovery by L-arginine is abolished by FGF-2. FGF-2 was ineffective when it was applied together with the calcium chelator ethylene glycol-bis(2-aminoethylether)tetraacetate (EGTA). The results indicate a possible role of FGF in the regulation of NO and calcium in photoreceptor cells and may explain protective effects of FGF in degenerative processes of photoreceptor cells.

References

Jun 30, 1992·Biochemical and Biophysical Research Communications·A MargulisA Sitaramayya
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M M LaVailR H Steinberg
Oct 31, 1991·Biochemical and Biophysical Research Communications·C M VenturiniS Moncada
Feb 1, 1988·Pflügers Archiv : European journal of physiology·M Pusch, E Neher
Jan 1, 1989·Visual Neuroscience·K F SchmidtC Baumann
Mar 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K F SchmidtC Baumann

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Citations

May 1, 1997·Visual Neuroscience·D M Allen, T E Hallows
Jul 11, 1998·Experimental Eye Research·M E CarwileT W Kraft

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