Fibroblast growth factors, old kids on the new block

Seminars in Cell & Developmental Biology
Xiaokun LiFen Wang

Abstract

The fibroblast growth factors (FGFs) are a family of cell intrinsic regulatory peptides that control a broad spectrum of cellular activities. The family includes canonic FGFs that elicit their activities by activating the FGF receptor (FGFR) tyrosine kinase and non-canonic members that elicit their activities intracellularly and via FGFR-independent mechanisms. The FGF signaling axis is highly complex due to the existence of multiple isoforms of both ligands and receptors, as well as cofactors that include the chemically heterogeneous heparan sulfate (HS) cofactors, and in the case of endocrine FGFs, the Klotho coreceptors. Resident FGF signaling controls embryonic development, maintains tissue homeostasis, promotes wound healing and tissue regeneration, and regulates functions of multiple organs. However, ectopic or aberrant FGF signaling is a culprit for various diseases, including congenital birth defects, metabolic disorder, and cancer. The molecular mechanisms by which the specificity of FGF signaling is achieved remain incompletely understood. Since its application as a druggable target has been gradually recognized by pharmaceutical companies and translational researchers, understanding the determinants of FGF signaling ...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TanakaK Matsumoto
Jan 1, 1991·Annals of the New York Academy of Sciences·K KeeganM J Hayman
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y HattoriM Terada
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J S RubinS A Aaronson
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M TairaT Sugimura
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H SakamotoT Sugimura
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H A Armelin
Aug 1, 1993·The British Journal of Surgery·E UhlK Messmer
Jun 1, 1993·American Journal of Surgery·N T Bennett, G S Schultz
Aug 1, 1995·Trends in Genetics : TIG·M Muenke, U Schell
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P M SmallwoodJ Nathans
May 1, 1997·Trends in Genetics : TIG·M K Webster, D J Donoghue
Sep 20, 1997·The Journal of Biological Chemistry·F WangW L McKeehan
Sep 23, 1997·Biochemical and Biophysical Research Communications·S H OngG R Guy
Feb 25, 1998·Biochemical and Biophysical Research Communications·A MiyakeN Itoh
Mar 26, 1998·Biochemical and Biophysical Research Communications·M HoshikawaN Itoh
Apr 16, 1998·Trends in Biochemical Sciences·D BurkeS Malcolm
Jul 11, 1998·The Journal of Biological Chemistry·N OhbayashiN Itoh
Nov 18, 1998·Current Opinion in Structural Biology·S FahamD C Rees
Feb 5, 1999·Biochimica Et Biophysica Acta·T NishimuraN Itoh
Feb 17, 1999·Frontiers in Bioscience : a Journal and Virtual Library·P Klint, L Claesson-Welsh
Apr 23, 1999·The Journal of Biological Chemistry·W LuW L McKeehan

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Citations

May 29, 2016·Cellular and Molecular Life Sciences : CMLS·Sivadasan Bindu DhaneshJackson James
Jun 9, 2016·Cellular Signalling·Alfonso Saera-VilaAlon Kahana
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Marianne Deries, Sólveig Thorsteinsdóttir
Jul 8, 2016·Cell Proliferation·Qian JingJingyi Li
Nov 20, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sergio MencheroMiguel Manzanares
Dec 18, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David M Ornitz, Laurence Legeai-Mallet
Apr 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stephanie A Kleine, Steven C Budsberg
Sep 10, 2019·Frontiers of Medicine·Xiaokun Li
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Fen WangCong Wang
Feb 15, 2019·Frontiers in Genetics·Cong WangFen Wang
Mar 7, 2020·Frontiers in Cell and Developmental Biology·Majid Mossahebi-MohammadiXiaokun Li
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Cong WangXuebo Pan
Mar 20, 2020·International Journal of Molecular Sciences·Sobhani NavidYong Li
Mar 4, 2021·Cell Proliferation·Guihong LiuXiawei Wei
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta
Apr 3, 2021·Frontiers in Molecular Biosciences·Changkai Bu, Lan Jin
Apr 17, 2021·Molecular Neurobiology·Lars Klimaschewski, Peter Claus
Dec 25, 2021·The FEBS Journal·Hiba-Tun-Noor Afshan MahmoodAthina-Myrto Chioni

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