Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ.

Cancer Research
Christopher JedeszkoBonnie F Sloane

Abstract

Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the regulation of tumor cell migration and invasion. The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive breast carcinoma is marked by infiltration of stromal fibroblasts and the loss of basement membrane. We hypothesized that HGF produced by the infiltrating fibroblasts may alter proteolytic pathways in DCIS cells, and, to study this hypothesis, established three-dimensional reconstituted basement membrane overlay cocultures with two human DCIS cell lines, MCF10.DCIS and SUM102. Both cell lines formed large dysplastic structures in three-dimensional cultures that resembled DCIS in vivo and occasionally developed invasive outgrowths. In coculture with HGF-secreting mammary fibroblasts, the percentage of DCIS structures with invasive outgrowths was increased. Activation of c-Met with conditioned medium from HGF-secreting fibroblasts or with recombinant HGF increased the percentage of DCIS structures with invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasminogen activator and its receptor. In agreement with the...Continue Reading

References

Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·H SakuraiS K Nigam
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·L BevigliaR H Kramer
Jul 25, 2000·Journal of the National Cancer Institute·M Miller
Jul 25, 2000·Journal of the National Cancer Institute·A M Senderowicz, E A Sausville
Jul 25, 2000·Journal of the National Cancer Institute·F R MillerP J Dawson
May 18, 2001·Nature·L A Liotta, E C Kohn
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Apr 6, 2002·Canadian Journal of Physiology and Pharmacology·Bruce E ElliottAlan B Tuck
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Omaida C VelazquezMeenhard Herlyn
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Feb 3, 2005·Cell Research·Chong Feng Gao, George F Vande Woude
Apr 21, 2005·Thrombosis and Haemostasis·Keld DanøJohn Rømer
Sep 9, 2005·Nature Reviews. Cancer·Jayanta Debnath, Joan S Brugge
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Mar 31, 2007·Nature Methods·Genee Y LeeMina J Bissell
May 22, 2007·Biochemical Society Transactions·D QiuV Ellis
Nov 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E C KoonS C Mok
Jan 5, 2008·Cancer Metastasis Reviews·Alessandra GentilePaolo M Comoglio
May 6, 2008·Cancer Cell·Min HuKornelia Polyak
May 31, 2008·Nature Reviews. Drug Discovery·Paolo M ComoglioLivio Trusolino
Jun 14, 2008·Expert Opinion on Investigational Drugs·Xiangdong LiuPeggy A Scherle
Jun 14, 2008·Current Protocols in Cell Biology·Christopher JedeszkoBonnie F Sloane
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew P Mazar
Dec 17, 2008·Clinical & Experimental Metastasis·Mansoureh SameniBonnie F Sloane

❮ Previous
Next ❯

Citations

Sep 7, 2011·Breast Cancer Research and Treatment·Brant PohorelicA Magliocco
Nov 22, 2011·Cancer Metastasis Reviews·Paolo Cirri, Paola Chiarugi
Nov 15, 2011·Breast Cancer Research : BCR·Andrew E PlaceKornelia Polyak
Mar 1, 2012·Journal of Visualized Experiments : JoVE·Mansoureh SameniBonnie F Sloane
Jul 30, 2014·The Journal of Experimental Medicine·Daniel ÖhlundDavid Tuveson
Sep 13, 2013·Breast Cancer Research : BCR·Patricia Casbas-HernandezMelissa A Troester
Jul 23, 2014·The Journal of Cell Biology·Emanuela FrittoliGiorgio Scita
Nov 12, 2013·Expert Opinion on Investigational Drugs·Monika Ehnman, Arne Östman
Sep 17, 2015·Biochimie·Kyungmin JiBonnie F Sloane
Aug 30, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Keisei TachibanaMasayuki Noguchi
May 11, 2010·Experimental Cell Research·Kati Räsänen, Antti Vaheri
Jan 14, 2010·Experimental Cell Research·Cyrus M GhajarAndrew J Putnam
Oct 27, 2015·Breast Cancer Research and Treatment·Neha AggarwalBonnie F Sloane
Jun 12, 2013·Biochimie·Ludovic ZimmerlinAlbert D Donnenberg
Aug 23, 2011·Biochimica Et Biophysica Acta·Jennifer M RothbergBonnie F Sloane
Apr 19, 2012·Upsala Journal of Medical Sciences·Carina StrellArne Ostman
May 28, 2015·BMC Gastroenterology·Alexandra I ThompsonNeil C Henderson
Apr 19, 2015·Breast Cancer Research : BCR·Colan M Ho-YenStephanie Kermorgant
Feb 16, 2017·Nature Communications·Juan R Hernandez-FernaudSara Zanivan
Jun 18, 2017·Chemical Communications : Chem Comm·Rachael M KenneyMatthew R Lockett
Jul 15, 2015·Lab on a Chip·Yoonseok ChoiDongeun Huh
May 26, 2017·International Journal of Cancer. Journal International Du Cancer·Xiaofeng WangLiping Su
Oct 18, 2018·The Analyst·Rachael M KenneyMatthew R Lockett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.