Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

European Journal of Cell Biology
Gopu SriramMei Bigliardi-Qi

Abstract

Advances in cell culture methods, multidisciplinary research, clinical need to replace lost skin tissues and regulatory need to replace animal models with alternative test methods has led to development of three dimensional models of human skin. In general, these in vitro models of skin consist of keratinocytes cultured over fibroblast-populated dermal matrices. Accumulating evidences indicate that mesenchyme-derived signals are essential for epidermal morphogenesis, homeostasis and differentiation. Various studies show that fibroblasts isolated from different tissues in the body are dynamic in nature and are morphologically and functionally heterogeneous subpopulations. Further, these differences seem to be dictated by the local biological and physical microenvironment the fibroblasts reside resulting in "positional identity or memory". Furthermore, the heterogeneity among the fibroblasts play a critical role in scarless wound healing and complete restoration of native tissue architecture in fetus and oral mucosa; and excessive scar formation in diseased states like keloids and hypertrophic scars. In this review, we summarize current concepts about the heterogeneity among fibroblasts and their role in various wound healing env...Continue Reading

References

Mar 23, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·U Rowlatt
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S WernerL T Williams
May 1, 1992·The Journal of Cell Biology·A König, L Bruckner-Tuderman
Jan 1, 1992·Annals of Surgery·N S Adzick, M T Longaker
Sep 1, 1991·Developmental Biology·D J Whitby, M W Ferguson
Sep 1, 1991·The Journal of Surgical Research·N S Adzick, M T Longaker
Apr 1, 1989·The British Journal of Dermatology·R R IsseroffR M Rosenberg
Jun 1, 1989·Developmental Biology·D AsselineauM Darmon
Oct 1, 1988·Annals of Plastic Surgery·G G HallockB R DiPaolo
Jan 1, 1988·Journal of Cell Science. Supplement·K BayreutherK Maier
Oct 1, 1987·The Laryngoscope·S A EstremA E Cram
Sep 1, 1987·The Journal of Burn Care & Rehabilitation·E C RobbJ W Alexander
Apr 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·J R MerkelD C Rice
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K BayreutherP I Francz
Apr 1, 1986·The British Journal of Dermatology·A G MessengerS S Bleehen
Nov 1, 1995·Plastic and Reconstructive Surgery·H P LorenzN S Adzick
Aug 1, 1994·Journal of Pediatric Surgery·S M AlaishI K Cohen
Jul 1, 1995·The Journal of Cell Biology·F StrutzE G Neilson
Apr 1, 1995·Differentiation; Research in Biological Diversity·D Asselineau, M Darmon
Sep 1, 1994·Clinical Immunology and Immunopathology·K M FriesR P Phipps
Aug 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M P MarinkovichR E Burgeson
Jan 1, 1994·Annals of Surgery·M T LongakerN S Adzick
Nov 1, 1993·Matrix : Collagen and Related Research·B A MastI K Cohen
Jul 1, 1993·The Journal of Cell Biology·H SmolaN E Fusenig
Apr 1, 1993·Journal of Dermatological Science·E Okamoto, Y Kitano
Apr 1, 1993·Annals of Surgery·H P LorenzN S Adzick
Apr 1, 1993·Journal of Pharmaceutical Sciences·M RegnierH Schaefer
Mar 1, 1993·Annals of Plastic Surgery·G G HallockB R DiPaolo

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Citations

Feb 24, 2016·Journal of Biomechanics·Hanneke N MonsuurSusan Gibbs
May 24, 2016·The Journal of Investigative Dermatology·Colin A B Jahoda, Adam C Gilmore
Jul 14, 2016·Tissue Engineering. Part C, Methods·Jeroen K BuskermolenSusan Gibbs
May 7, 2016·Genes & Development·Philippe Gascard, Thea D Tlsty
Mar 16, 2017·Development·Hsing-Jung WuJohn Foley
Apr 8, 2017·Journal of Cellular Physiology·Jeroen K BuskermolenSusan Gibbs
Jul 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Joo YangKi Woo Kim
Mar 28, 2018·International Journal of Molecular Sciences·Elina ChermnykhEkaterina Vorotelyak
Nov 14, 2017·Tissue Engineering. Part a·Arnout MieremetAbdoelwaheb El Ghalbzouri
Jan 24, 2018·Advanced Healthcare Materials·Seungkuk AhnKevin Kit Parker
Nov 18, 2017·Scientific Reports·Paul Lorenz BigliardiMei Bigliardi-Qi
Jun 7, 2017·Biofabrication·Byoung Soo KimDong-Woo Cho
Aug 24, 2016·Nature Reviews. Cancer·Raghu Kalluri
May 15, 2018·Journal of Tissue Engineering and Regenerative Medicine·Yang WuJerry Ying Hsi Fuh
Jul 13, 2018·Journal of Biomaterials Science. Polymer Edition·Cemile Kilic BektasNesrin Hasirci
Feb 9, 2018·Nanoscale Research Letters·Alyona SukhanovaIgor Nabiev
Feb 15, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maribanyana LebekoArdeshir Bayat
Jan 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diana GasparDimitrios I Zeugolis
Apr 3, 2019·Tissue Engineering. Part B, Reviews·Mehri MonavarianEsmaiel Jabbari
Apr 14, 2019·Journal of Cellular and Molecular Medicine·Anna Maria SaccoClotilde Castaldo
Jun 16, 2017·Nature Reviews. Rheumatology·Caroline Ospelt, Mojca Frank-Bertoncelj
Aug 23, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yanhai ZuoHui Chen
Aug 24, 2019·Cell Proliferation·Sarah E Vidal YuchaDavid L Kaplan
Jul 12, 2019·Journal of Virology·Gaurav RaikhyJason M Bodily
Jul 5, 2016·Experimental Dermatology·Olivier BornertAlexander Nyström
Apr 9, 2020·American Journal of Physiology. Cell Physiology·Georgia NikoloudakiDouglas W Hamilton
Mar 12, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Parisa RamhormoziMaliheh Nobakht
Sep 25, 2020·Journal of Periodontal Research·Srividya AtkuruGopu Sriram
Jun 1, 2016·Journal of Applied Toxicology : JAT·Harish K HandralTong Cao
Sep 16, 2017·Scientific Reports·Rinat Tzach-NahmanGabriel Nussbaum
Apr 21, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ankit Roy ChoudhuryDeepak Pandey

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