Fibroblast state switching orchestrates dermal maturation and wound healing

Molecular Systems Biology
Emanuel RognoniFiona M Watt

Abstract

Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture. Virtual-tissue simulations of our model faithfully recapitulate dermal maturation, predicting a loss of spatial segregation of fibroblast lineages and dictating that fibroblast migration is only required for wound healing. To test this, we performed in vivo live imaging of dermal fibroblasts, which revealed that homeostatic tissue architecture is achieved without active cell migration. In contrast, both fibroblast proliferation and migration are key determinants of tissue repair following wounding. The results show that tissue-scale coordination is driven by the interdependence of cell proliferation and ECM deposition, paving the way for identifying new therapeutic strategies to enhance skin regeneration.

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Citations

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Datasets Mentioned

BETA
GSE32966

Methods Mentioned

BETA
flow cytometry
transgenic
biopsy
FACS

Software Mentioned

Icy
Photoshop CS6
Nikon ND2 Viewer
Mathematica
CompuCell3D
GrowthSteppable
Fiji
FlowJo
AOP
TransitionSteppable

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