Fibroblastic Malignant Peripheral Nerve Sheath Tumour of the Uterine Cervix: Report of a Case and Literature Review With Emphasis on Possible Differential Diagnosis

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Valentina SangiorgioEnzo Ricciardi

Abstract

Cervical sarcomas are rare neoplasms, accounting for <1% of all cervical malignancies and characterized by an aggressive course despite radical excision. We report the clinical and microscopic features of a spindle cell sarcoma arising as a polypoid endocervical mass in a 45-yr-old woman. The neoplasm was characterized by a monotonous, mildly atypical proliferation of spindle cells, displaying a fibrosarcoma-like parallel pattern of highly dense fascicles, growing under the cervical epithelium. Mitotic activity was conspicuous, with up to 40 mitoses per 10 HPF. On immunohistochemistry, tumor cells were patchy S-100 protein positive. Additional immunohistochemical markers performed to rule out smooth muscle, melanocytic, epithelial, and sarcomatous differentiation were negative. A possible monophasic synovial sarcoma was also excluded by negative fluorescence in situ hybridization t(X;18) analysis. Interestingly, the neoplasm showed a focal CD34 positivity, as reported in normal fibrocytic cells of the endocervical stroma. Giving the morphologic and immunohistochemical features, the neoplasm was eventually defined as malignant peripheral nerve sheath tumor. Histologic examination following radical surgery revealed the neoplasm w...Continue Reading

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Citations

Mar 17, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sabrina CroceW Glenn McCluggage
Feb 12, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anjelica HodgsonGulisa Turashvili
Oct 20, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Elmira Vaziri FardMichael Covinsky
Dec 29, 2020·Indian Journal of Surgical Oncology·Aswathy G NathNeelima Radhakrishnan
Sep 22, 2020·Gynecologic Oncology Reports·Yi Alexander ChuangChye Lee Kho
Oct 30, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jiaoling LiHaiying Wu

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Methods Mentioned

BETA
hysterectomy
electron microscopy

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